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Impact of Maternal Antibodies on Infectious Bronchitis Virus (IBV) Infection in Primary and Secondary Lymphoid Organs of Chickens

Infectious bronchitis virus (IBV) causes infectious bronchitis disease in chickens. IBV primarily infects the upper respiratory tract and then disseminates to other body systems including gastrointestinal, reproductive, and urinary systems. Unlike original IBV serotypes, the novel IBV variants targe...

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Autores principales: Isham, Ishara M., Hassan, Mohamed S. H., Abd-Elsalam, Reham M., Ranaweera, Hiruni A., Mahmoud, Motamed E., Najimudeen, Shahnas M., Ghaffar, Awais, Cork, Susan C., Gupta, Ashish, Abdul-Careem, Mohamed Faizal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10384813/
https://www.ncbi.nlm.nih.gov/pubmed/37515032
http://dx.doi.org/10.3390/vaccines11071216
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author Isham, Ishara M.
Hassan, Mohamed S. H.
Abd-Elsalam, Reham M.
Ranaweera, Hiruni A.
Mahmoud, Motamed E.
Najimudeen, Shahnas M.
Ghaffar, Awais
Cork, Susan C.
Gupta, Ashish
Abdul-Careem, Mohamed Faizal
author_facet Isham, Ishara M.
Hassan, Mohamed S. H.
Abd-Elsalam, Reham M.
Ranaweera, Hiruni A.
Mahmoud, Motamed E.
Najimudeen, Shahnas M.
Ghaffar, Awais
Cork, Susan C.
Gupta, Ashish
Abdul-Careem, Mohamed Faizal
author_sort Isham, Ishara M.
collection PubMed
description Infectious bronchitis virus (IBV) causes infectious bronchitis disease in chickens. IBV primarily infects the upper respiratory tract and then disseminates to other body systems including gastrointestinal, reproductive, and urinary systems. Unlike original IBV serotypes, the novel IBV variants target lymphoid organs, but information on this is scarce. In this study, we aim to evaluate the impact of the presence of maternal antibodies on IBV infection in primary and secondary lymphoid organs. Maternal antibody free, specific pathogen free (SPF) hens were divided into vaccinated and non-vaccinated groups. The progeny male chicks from these hens were divided into four groups; vaccinated challenged (VC), non-vaccinated challenged (NVC), vaccinated non-challenged (VNC), and non-vaccinated non-challenged (NVNC). The challenge groups were given 1 × 10(6) embryo infectious dose (EID)(50) of IBV Delmarva (DMV)/1639 by the oculo-nasal route and non-challenge groups were given saline. The serum anti-IBV antibody titer was significantly higher in challenged groups compared to non-challenged groups. The IBV genome load was significantly lower in the VC group than NVC group in oropharyngeal and cloacal swabs and in bursa of Fabricius (BF) and cecal tonsils (CT). The histopathological lesion scores were significantly lower in VC group than NVC group in BF and CT. These findings suggest that the presence of maternal antibody in chicks could provide some degree of protection against IBV infection in BF and CT.
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spelling pubmed-103848132023-07-30 Impact of Maternal Antibodies on Infectious Bronchitis Virus (IBV) Infection in Primary and Secondary Lymphoid Organs of Chickens Isham, Ishara M. Hassan, Mohamed S. H. Abd-Elsalam, Reham M. Ranaweera, Hiruni A. Mahmoud, Motamed E. Najimudeen, Shahnas M. Ghaffar, Awais Cork, Susan C. Gupta, Ashish Abdul-Careem, Mohamed Faizal Vaccines (Basel) Article Infectious bronchitis virus (IBV) causes infectious bronchitis disease in chickens. IBV primarily infects the upper respiratory tract and then disseminates to other body systems including gastrointestinal, reproductive, and urinary systems. Unlike original IBV serotypes, the novel IBV variants target lymphoid organs, but information on this is scarce. In this study, we aim to evaluate the impact of the presence of maternal antibodies on IBV infection in primary and secondary lymphoid organs. Maternal antibody free, specific pathogen free (SPF) hens were divided into vaccinated and non-vaccinated groups. The progeny male chicks from these hens were divided into four groups; vaccinated challenged (VC), non-vaccinated challenged (NVC), vaccinated non-challenged (VNC), and non-vaccinated non-challenged (NVNC). The challenge groups were given 1 × 10(6) embryo infectious dose (EID)(50) of IBV Delmarva (DMV)/1639 by the oculo-nasal route and non-challenge groups were given saline. The serum anti-IBV antibody titer was significantly higher in challenged groups compared to non-challenged groups. The IBV genome load was significantly lower in the VC group than NVC group in oropharyngeal and cloacal swabs and in bursa of Fabricius (BF) and cecal tonsils (CT). The histopathological lesion scores were significantly lower in VC group than NVC group in BF and CT. These findings suggest that the presence of maternal antibody in chicks could provide some degree of protection against IBV infection in BF and CT. MDPI 2023-07-07 /pmc/articles/PMC10384813/ /pubmed/37515032 http://dx.doi.org/10.3390/vaccines11071216 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Isham, Ishara M.
Hassan, Mohamed S. H.
Abd-Elsalam, Reham M.
Ranaweera, Hiruni A.
Mahmoud, Motamed E.
Najimudeen, Shahnas M.
Ghaffar, Awais
Cork, Susan C.
Gupta, Ashish
Abdul-Careem, Mohamed Faizal
Impact of Maternal Antibodies on Infectious Bronchitis Virus (IBV) Infection in Primary and Secondary Lymphoid Organs of Chickens
title Impact of Maternal Antibodies on Infectious Bronchitis Virus (IBV) Infection in Primary and Secondary Lymphoid Organs of Chickens
title_full Impact of Maternal Antibodies on Infectious Bronchitis Virus (IBV) Infection in Primary and Secondary Lymphoid Organs of Chickens
title_fullStr Impact of Maternal Antibodies on Infectious Bronchitis Virus (IBV) Infection in Primary and Secondary Lymphoid Organs of Chickens
title_full_unstemmed Impact of Maternal Antibodies on Infectious Bronchitis Virus (IBV) Infection in Primary and Secondary Lymphoid Organs of Chickens
title_short Impact of Maternal Antibodies on Infectious Bronchitis Virus (IBV) Infection in Primary and Secondary Lymphoid Organs of Chickens
title_sort impact of maternal antibodies on infectious bronchitis virus (ibv) infection in primary and secondary lymphoid organs of chickens
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10384813/
https://www.ncbi.nlm.nih.gov/pubmed/37515032
http://dx.doi.org/10.3390/vaccines11071216
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