Cargando…
The Effect of MSTN Mutation on Bile Acid Metabolism and Lipid Metabolism in Cattle
Myostatin (MSTN) is a negative regulator of skeletal muscle genesis during development. MSTN mutation leads to increased lean meat production and reduced fat deposition in livestock. However, the mechanism by which MSTN promotes myogenesis by regulating metabolism is not clear. In this study, we com...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10384915/ https://www.ncbi.nlm.nih.gov/pubmed/37512543 http://dx.doi.org/10.3390/metabo13070836 |
_version_ | 1785081274928463872 |
---|---|
author | Wu, Di Wang, Song Hai, Chao Wang, Linfeng Pei, Dongchao Bai, Chunling Su, Guanghua Liu, Xuefei Zhao, Yuefang Liu, Zhonghua Yang, Lei Li, Guangpeng |
author_facet | Wu, Di Wang, Song Hai, Chao Wang, Linfeng Pei, Dongchao Bai, Chunling Su, Guanghua Liu, Xuefei Zhao, Yuefang Liu, Zhonghua Yang, Lei Li, Guangpeng |
author_sort | Wu, Di |
collection | PubMed |
description | Myostatin (MSTN) is a negative regulator of skeletal muscle genesis during development. MSTN mutation leads to increased lean meat production and reduced fat deposition in livestock. However, the mechanism by which MSTN promotes myogenesis by regulating metabolism is not clear. In this study, we compared the metabolomics of the livers of wild-type (WT) and MSTN mutation cattle (MT), and found changes in the content and proportion of fatty acids and bile acids in MT cattle. The differential metabolites were enriched in sterol synthesis and primary bile acid synthesis. We further analyzed the expression of genes involved in the regulation of lipid and bile acid metabolism, and found that the loss of MSTN may alter lipid synthesis and bile acid metabolism. This study provides new basic data for MSTN mutations in beef cattle breeding. |
format | Online Article Text |
id | pubmed-10384915 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103849152023-07-30 The Effect of MSTN Mutation on Bile Acid Metabolism and Lipid Metabolism in Cattle Wu, Di Wang, Song Hai, Chao Wang, Linfeng Pei, Dongchao Bai, Chunling Su, Guanghua Liu, Xuefei Zhao, Yuefang Liu, Zhonghua Yang, Lei Li, Guangpeng Metabolites Article Myostatin (MSTN) is a negative regulator of skeletal muscle genesis during development. MSTN mutation leads to increased lean meat production and reduced fat deposition in livestock. However, the mechanism by which MSTN promotes myogenesis by regulating metabolism is not clear. In this study, we compared the metabolomics of the livers of wild-type (WT) and MSTN mutation cattle (MT), and found changes in the content and proportion of fatty acids and bile acids in MT cattle. The differential metabolites were enriched in sterol synthesis and primary bile acid synthesis. We further analyzed the expression of genes involved in the regulation of lipid and bile acid metabolism, and found that the loss of MSTN may alter lipid synthesis and bile acid metabolism. This study provides new basic data for MSTN mutations in beef cattle breeding. MDPI 2023-07-11 /pmc/articles/PMC10384915/ /pubmed/37512543 http://dx.doi.org/10.3390/metabo13070836 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Wu, Di Wang, Song Hai, Chao Wang, Linfeng Pei, Dongchao Bai, Chunling Su, Guanghua Liu, Xuefei Zhao, Yuefang Liu, Zhonghua Yang, Lei Li, Guangpeng The Effect of MSTN Mutation on Bile Acid Metabolism and Lipid Metabolism in Cattle |
title | The Effect of MSTN Mutation on Bile Acid Metabolism and Lipid Metabolism in Cattle |
title_full | The Effect of MSTN Mutation on Bile Acid Metabolism and Lipid Metabolism in Cattle |
title_fullStr | The Effect of MSTN Mutation on Bile Acid Metabolism and Lipid Metabolism in Cattle |
title_full_unstemmed | The Effect of MSTN Mutation on Bile Acid Metabolism and Lipid Metabolism in Cattle |
title_short | The Effect of MSTN Mutation on Bile Acid Metabolism and Lipid Metabolism in Cattle |
title_sort | effect of mstn mutation on bile acid metabolism and lipid metabolism in cattle |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10384915/ https://www.ncbi.nlm.nih.gov/pubmed/37512543 http://dx.doi.org/10.3390/metabo13070836 |
work_keys_str_mv | AT wudi theeffectofmstnmutationonbileacidmetabolismandlipidmetabolismincattle AT wangsong theeffectofmstnmutationonbileacidmetabolismandlipidmetabolismincattle AT haichao theeffectofmstnmutationonbileacidmetabolismandlipidmetabolismincattle AT wanglinfeng theeffectofmstnmutationonbileacidmetabolismandlipidmetabolismincattle AT peidongchao theeffectofmstnmutationonbileacidmetabolismandlipidmetabolismincattle AT baichunling theeffectofmstnmutationonbileacidmetabolismandlipidmetabolismincattle AT suguanghua theeffectofmstnmutationonbileacidmetabolismandlipidmetabolismincattle AT liuxuefei theeffectofmstnmutationonbileacidmetabolismandlipidmetabolismincattle AT zhaoyuefang theeffectofmstnmutationonbileacidmetabolismandlipidmetabolismincattle AT liuzhonghua theeffectofmstnmutationonbileacidmetabolismandlipidmetabolismincattle AT yanglei theeffectofmstnmutationonbileacidmetabolismandlipidmetabolismincattle AT liguangpeng theeffectofmstnmutationonbileacidmetabolismandlipidmetabolismincattle AT wudi effectofmstnmutationonbileacidmetabolismandlipidmetabolismincattle AT wangsong effectofmstnmutationonbileacidmetabolismandlipidmetabolismincattle AT haichao effectofmstnmutationonbileacidmetabolismandlipidmetabolismincattle AT wanglinfeng effectofmstnmutationonbileacidmetabolismandlipidmetabolismincattle AT peidongchao effectofmstnmutationonbileacidmetabolismandlipidmetabolismincattle AT baichunling effectofmstnmutationonbileacidmetabolismandlipidmetabolismincattle AT suguanghua effectofmstnmutationonbileacidmetabolismandlipidmetabolismincattle AT liuxuefei effectofmstnmutationonbileacidmetabolismandlipidmetabolismincattle AT zhaoyuefang effectofmstnmutationonbileacidmetabolismandlipidmetabolismincattle AT liuzhonghua effectofmstnmutationonbileacidmetabolismandlipidmetabolismincattle AT yanglei effectofmstnmutationonbileacidmetabolismandlipidmetabolismincattle AT liguangpeng effectofmstnmutationonbileacidmetabolismandlipidmetabolismincattle |