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The Effect of MSTN Mutation on Bile Acid Metabolism and Lipid Metabolism in Cattle

Myostatin (MSTN) is a negative regulator of skeletal muscle genesis during development. MSTN mutation leads to increased lean meat production and reduced fat deposition in livestock. However, the mechanism by which MSTN promotes myogenesis by regulating metabolism is not clear. In this study, we com...

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Autores principales: Wu, Di, Wang, Song, Hai, Chao, Wang, Linfeng, Pei, Dongchao, Bai, Chunling, Su, Guanghua, Liu, Xuefei, Zhao, Yuefang, Liu, Zhonghua, Yang, Lei, Li, Guangpeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10384915/
https://www.ncbi.nlm.nih.gov/pubmed/37512543
http://dx.doi.org/10.3390/metabo13070836
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author Wu, Di
Wang, Song
Hai, Chao
Wang, Linfeng
Pei, Dongchao
Bai, Chunling
Su, Guanghua
Liu, Xuefei
Zhao, Yuefang
Liu, Zhonghua
Yang, Lei
Li, Guangpeng
author_facet Wu, Di
Wang, Song
Hai, Chao
Wang, Linfeng
Pei, Dongchao
Bai, Chunling
Su, Guanghua
Liu, Xuefei
Zhao, Yuefang
Liu, Zhonghua
Yang, Lei
Li, Guangpeng
author_sort Wu, Di
collection PubMed
description Myostatin (MSTN) is a negative regulator of skeletal muscle genesis during development. MSTN mutation leads to increased lean meat production and reduced fat deposition in livestock. However, the mechanism by which MSTN promotes myogenesis by regulating metabolism is not clear. In this study, we compared the metabolomics of the livers of wild-type (WT) and MSTN mutation cattle (MT), and found changes in the content and proportion of fatty acids and bile acids in MT cattle. The differential metabolites were enriched in sterol synthesis and primary bile acid synthesis. We further analyzed the expression of genes involved in the regulation of lipid and bile acid metabolism, and found that the loss of MSTN may alter lipid synthesis and bile acid metabolism. This study provides new basic data for MSTN mutations in beef cattle breeding.
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spelling pubmed-103849152023-07-30 The Effect of MSTN Mutation on Bile Acid Metabolism and Lipid Metabolism in Cattle Wu, Di Wang, Song Hai, Chao Wang, Linfeng Pei, Dongchao Bai, Chunling Su, Guanghua Liu, Xuefei Zhao, Yuefang Liu, Zhonghua Yang, Lei Li, Guangpeng Metabolites Article Myostatin (MSTN) is a negative regulator of skeletal muscle genesis during development. MSTN mutation leads to increased lean meat production and reduced fat deposition in livestock. However, the mechanism by which MSTN promotes myogenesis by regulating metabolism is not clear. In this study, we compared the metabolomics of the livers of wild-type (WT) and MSTN mutation cattle (MT), and found changes in the content and proportion of fatty acids and bile acids in MT cattle. The differential metabolites were enriched in sterol synthesis and primary bile acid synthesis. We further analyzed the expression of genes involved in the regulation of lipid and bile acid metabolism, and found that the loss of MSTN may alter lipid synthesis and bile acid metabolism. This study provides new basic data for MSTN mutations in beef cattle breeding. MDPI 2023-07-11 /pmc/articles/PMC10384915/ /pubmed/37512543 http://dx.doi.org/10.3390/metabo13070836 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wu, Di
Wang, Song
Hai, Chao
Wang, Linfeng
Pei, Dongchao
Bai, Chunling
Su, Guanghua
Liu, Xuefei
Zhao, Yuefang
Liu, Zhonghua
Yang, Lei
Li, Guangpeng
The Effect of MSTN Mutation on Bile Acid Metabolism and Lipid Metabolism in Cattle
title The Effect of MSTN Mutation on Bile Acid Metabolism and Lipid Metabolism in Cattle
title_full The Effect of MSTN Mutation on Bile Acid Metabolism and Lipid Metabolism in Cattle
title_fullStr The Effect of MSTN Mutation on Bile Acid Metabolism and Lipid Metabolism in Cattle
title_full_unstemmed The Effect of MSTN Mutation on Bile Acid Metabolism and Lipid Metabolism in Cattle
title_short The Effect of MSTN Mutation on Bile Acid Metabolism and Lipid Metabolism in Cattle
title_sort effect of mstn mutation on bile acid metabolism and lipid metabolism in cattle
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10384915/
https://www.ncbi.nlm.nih.gov/pubmed/37512543
http://dx.doi.org/10.3390/metabo13070836
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