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Changes in Biomarkers of Exposure and Potential Harm in Smokers Switched to Vuse Vibe or Vuse Ciro Electronic Nicotine Delivery Systems

Electronic nicotine delivery systems (ENDS) have the potential to provide nicotine to tobacco consumers while reducing exposure to combustion-related toxicants. Here, we report changes in biomarkers of exposure (BoE) and biomarkers of potential harm (BoPH) in smokers who completely switched to Vuse...

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Autores principales: Kanobe, Milly N., Nelson, Paul R., Brown, Buddy G., Chen, Peter, Makena, Patrudu, Caraway, John W., Prasad, Gaddamanugu L., Round, Elaine K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10384956/
https://www.ncbi.nlm.nih.gov/pubmed/37505530
http://dx.doi.org/10.3390/toxics11070564
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author Kanobe, Milly N.
Nelson, Paul R.
Brown, Buddy G.
Chen, Peter
Makena, Patrudu
Caraway, John W.
Prasad, Gaddamanugu L.
Round, Elaine K.
author_facet Kanobe, Milly N.
Nelson, Paul R.
Brown, Buddy G.
Chen, Peter
Makena, Patrudu
Caraway, John W.
Prasad, Gaddamanugu L.
Round, Elaine K.
author_sort Kanobe, Milly N.
collection PubMed
description Electronic nicotine delivery systems (ENDS) have the potential to provide nicotine to tobacco consumers while reducing exposure to combustion-related toxicants. Here, we report changes in biomarkers of exposure (BoE) and biomarkers of potential harm (BoPH) in smokers who completely switched to Vuse Vibe and Vuse Ciro ENDS products, or to smoking abstinence in a randomized, controlled clinical study. Thirteen BoE (12 urinary and one blood) that indicate exposure to harmful and potentially harmful toxicants (HPHCs) were evaluated at baseline on day 5. Urinary BoPH linked to oxidative stress, platelet activation, and inflammation were also assessed at baseline, and on day 5 and day 7. Nicotine exposure was lower in Vuse Vibe and Vuse Ciro groups compared to baseline values. Urinary non-nicotine BoE decreased significantly (52.3–96.7%) in the Vuse ENDS groups, and the reductions were similar in magnitude to those observed in the abstinence group. Blood carboxyhemoglobin decreased 52.8–55.0% in all study groups. Decreases (10–50%) in BoPH were observed in all study groups. Thus, smokers who switch exclusively to Vuse Vibe or Vuse Ciro products or completely abstain from smoking are exposed to substantially lower levels of HPHCs, and experience improvements in BoPH of oxidative stress and inflammation pathways.
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spelling pubmed-103849562023-07-30 Changes in Biomarkers of Exposure and Potential Harm in Smokers Switched to Vuse Vibe or Vuse Ciro Electronic Nicotine Delivery Systems Kanobe, Milly N. Nelson, Paul R. Brown, Buddy G. Chen, Peter Makena, Patrudu Caraway, John W. Prasad, Gaddamanugu L. Round, Elaine K. Toxics Article Electronic nicotine delivery systems (ENDS) have the potential to provide nicotine to tobacco consumers while reducing exposure to combustion-related toxicants. Here, we report changes in biomarkers of exposure (BoE) and biomarkers of potential harm (BoPH) in smokers who completely switched to Vuse Vibe and Vuse Ciro ENDS products, or to smoking abstinence in a randomized, controlled clinical study. Thirteen BoE (12 urinary and one blood) that indicate exposure to harmful and potentially harmful toxicants (HPHCs) were evaluated at baseline on day 5. Urinary BoPH linked to oxidative stress, platelet activation, and inflammation were also assessed at baseline, and on day 5 and day 7. Nicotine exposure was lower in Vuse Vibe and Vuse Ciro groups compared to baseline values. Urinary non-nicotine BoE decreased significantly (52.3–96.7%) in the Vuse ENDS groups, and the reductions were similar in magnitude to those observed in the abstinence group. Blood carboxyhemoglobin decreased 52.8–55.0% in all study groups. Decreases (10–50%) in BoPH were observed in all study groups. Thus, smokers who switch exclusively to Vuse Vibe or Vuse Ciro products or completely abstain from smoking are exposed to substantially lower levels of HPHCs, and experience improvements in BoPH of oxidative stress and inflammation pathways. MDPI 2023-06-29 /pmc/articles/PMC10384956/ /pubmed/37505530 http://dx.doi.org/10.3390/toxics11070564 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kanobe, Milly N.
Nelson, Paul R.
Brown, Buddy G.
Chen, Peter
Makena, Patrudu
Caraway, John W.
Prasad, Gaddamanugu L.
Round, Elaine K.
Changes in Biomarkers of Exposure and Potential Harm in Smokers Switched to Vuse Vibe or Vuse Ciro Electronic Nicotine Delivery Systems
title Changes in Biomarkers of Exposure and Potential Harm in Smokers Switched to Vuse Vibe or Vuse Ciro Electronic Nicotine Delivery Systems
title_full Changes in Biomarkers of Exposure and Potential Harm in Smokers Switched to Vuse Vibe or Vuse Ciro Electronic Nicotine Delivery Systems
title_fullStr Changes in Biomarkers of Exposure and Potential Harm in Smokers Switched to Vuse Vibe or Vuse Ciro Electronic Nicotine Delivery Systems
title_full_unstemmed Changes in Biomarkers of Exposure and Potential Harm in Smokers Switched to Vuse Vibe or Vuse Ciro Electronic Nicotine Delivery Systems
title_short Changes in Biomarkers of Exposure and Potential Harm in Smokers Switched to Vuse Vibe or Vuse Ciro Electronic Nicotine Delivery Systems
title_sort changes in biomarkers of exposure and potential harm in smokers switched to vuse vibe or vuse ciro electronic nicotine delivery systems
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10384956/
https://www.ncbi.nlm.nih.gov/pubmed/37505530
http://dx.doi.org/10.3390/toxics11070564
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