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Filter-Free, Harmless, and Single-Wavelength Far UV-C Germicidal Light for Reducing Airborne Pathogenic Viral Infection

Germicidal lamps that primarily emit 254 nm ultraviolet (UV) radiation have been effectively utilized for surface sterilization, but they cannot be used on human skin and eyes due to their harmful and genotoxic activity. Recent reports have shown that far UV-C light (207–222 nm) can efficiently kill...

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Autores principales: Truong, Cao-Sang, Muthukutty, Palaniyandi, Jang, Ho Kyung, Kim, Young-Ho, Lee, Dong Hoon, Yoo, So Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10385069/
https://www.ncbi.nlm.nih.gov/pubmed/37515151
http://dx.doi.org/10.3390/v15071463
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author Truong, Cao-Sang
Muthukutty, Palaniyandi
Jang, Ho Kyung
Kim, Young-Ho
Lee, Dong Hoon
Yoo, So Young
author_facet Truong, Cao-Sang
Muthukutty, Palaniyandi
Jang, Ho Kyung
Kim, Young-Ho
Lee, Dong Hoon
Yoo, So Young
author_sort Truong, Cao-Sang
collection PubMed
description Germicidal lamps that primarily emit 254 nm ultraviolet (UV) radiation have been effectively utilized for surface sterilization, but they cannot be used on human skin and eyes due to their harmful and genotoxic activity. Recent reports have shown that far UV-C light (207–222 nm) can efficiently kill pathogens with potentially no harm to exposed human tissues. However, these methods still require additional filtering and/or further protective equipment. In this study, we demonstrate a filter-free, harmless, and single-wavelength far UV-C 207 nm germicidal light source that can be used to inactivate different respiratory viruses. It can be exploited as a safe and effective disinfection tool for various airborne viruses. We successfully developed a single-wavelength far UV-C source that produces an exact wavelength of 207 nm. We examined its safety on human skin and corneal cell lines, as well as its effects on inactivating different airborne viruses, such as coronavirus, adenovirus, and vaccinia virus. We expect that our far UV-C lamps can be safely and conveniently used to reduce COVID-19 infections and protect both our living spaces and hospitals from the threat of contamination by possible new or mutant viruses.
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spelling pubmed-103850692023-07-30 Filter-Free, Harmless, and Single-Wavelength Far UV-C Germicidal Light for Reducing Airborne Pathogenic Viral Infection Truong, Cao-Sang Muthukutty, Palaniyandi Jang, Ho Kyung Kim, Young-Ho Lee, Dong Hoon Yoo, So Young Viruses Article Germicidal lamps that primarily emit 254 nm ultraviolet (UV) radiation have been effectively utilized for surface sterilization, but they cannot be used on human skin and eyes due to their harmful and genotoxic activity. Recent reports have shown that far UV-C light (207–222 nm) can efficiently kill pathogens with potentially no harm to exposed human tissues. However, these methods still require additional filtering and/or further protective equipment. In this study, we demonstrate a filter-free, harmless, and single-wavelength far UV-C 207 nm germicidal light source that can be used to inactivate different respiratory viruses. It can be exploited as a safe and effective disinfection tool for various airborne viruses. We successfully developed a single-wavelength far UV-C source that produces an exact wavelength of 207 nm. We examined its safety on human skin and corneal cell lines, as well as its effects on inactivating different airborne viruses, such as coronavirus, adenovirus, and vaccinia virus. We expect that our far UV-C lamps can be safely and conveniently used to reduce COVID-19 infections and protect both our living spaces and hospitals from the threat of contamination by possible new or mutant viruses. MDPI 2023-06-28 /pmc/articles/PMC10385069/ /pubmed/37515151 http://dx.doi.org/10.3390/v15071463 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Truong, Cao-Sang
Muthukutty, Palaniyandi
Jang, Ho Kyung
Kim, Young-Ho
Lee, Dong Hoon
Yoo, So Young
Filter-Free, Harmless, and Single-Wavelength Far UV-C Germicidal Light for Reducing Airborne Pathogenic Viral Infection
title Filter-Free, Harmless, and Single-Wavelength Far UV-C Germicidal Light for Reducing Airborne Pathogenic Viral Infection
title_full Filter-Free, Harmless, and Single-Wavelength Far UV-C Germicidal Light for Reducing Airborne Pathogenic Viral Infection
title_fullStr Filter-Free, Harmless, and Single-Wavelength Far UV-C Germicidal Light for Reducing Airborne Pathogenic Viral Infection
title_full_unstemmed Filter-Free, Harmless, and Single-Wavelength Far UV-C Germicidal Light for Reducing Airborne Pathogenic Viral Infection
title_short Filter-Free, Harmless, and Single-Wavelength Far UV-C Germicidal Light for Reducing Airborne Pathogenic Viral Infection
title_sort filter-free, harmless, and single-wavelength far uv-c germicidal light for reducing airborne pathogenic viral infection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10385069/
https://www.ncbi.nlm.nih.gov/pubmed/37515151
http://dx.doi.org/10.3390/v15071463
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