Cargando…

Fluorinated and N-Acryloyl-Modified 3,5-Di[(E)-benzylidene]piperidin-4-one Curcuminoids for the Treatment of Pancreatic Carcinoma

Pancreatic carcinoma is a cancer disease with high mortality. Thus, new and efficient treatments for this disease are badly needed. Curcumin has previously shown promising effects in pancreatic cancer patients; however, this natural compound suffers from inadequate efficacy and bioavailability, prev...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ghosh, Hindole, Bhattacharyya, Sangita, Schobert, Rainer, Dandawate, Prasad, Biersack, Bernhard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10385166/ https://www.ncbi.nlm.nih.gov/pubmed/37514107 http://dx.doi.org/10.3390/pharmaceutics15071921

Ejemplares similares

New 4,5-Diarylimidazol-2-ylidene–iodidogold(I) Complexes with High Activity against Esophageal Adenocarcinoma Cells
por: Schleser, Sebastian W., et al.
Publicado: (2023)

Synthesis and Anticancer Evaluation of New Indole-Based Tyrphostin Derivatives and Their (p-Cymene)dichloridoruthenium(II) Complexes
por: Oberhuber, Natalie, et al.
Publicado: (2023)

1-Acryloyl-2,6-bis(4-chlorophenyl)-3,5-dimethylpiperidin-4-one
por: Lakshminarayana, B. N., et al.
Publicado: (2009)

A New Synthetic Curcuminoid Displays Antitumor Activities in Metastasized Melanoma
por: Kaps, Leonard, et al.
Publicado: (2023)

(3E,5E)-1-Acryloyl-3,5-bis(2-chlorobenzylidene)piperidin-4-one
por: Basiri, Alireza, et al.
Publicado: (2011)

A New Pentafluorothio-Substituted Curcuminoid with Superior Antitumor Activity
por: Linder, Benedikt, et al.
Publicado: (2021)

(3E,5E)-1-Acryloyl-3,5-bis(2,4-dichlorobenzylidene)piperidin-4-one hemihydrate
por: Basiri, Alireza, et al.
Publicado: (2011)

3,5-Dimethyl-2,6-diphenylpiperidine
por: Sathya, S., et al.
Publicado: (2014)

N-(1-Acryloyl-2,2,6,6-tetramethylpiperidin-4-yl)acrylamide
por: Goswami, Shailesh K., et al.
Publicado: (2011)

N-Acryloyl glycinamide
por: Seuring, Jan, et al.
Publicado: (2011)

3D cell cultures, as a surrogate for animal models, enhance the diagnostic value of preclinical in vitro investigations by adding information on the tumour microenvironment: a comparative study of new dual-mode HDAC inhibitors
por: Bär, Sofia I., et al.
Publicado: (2022)

Accessing (Multi)Fluorinated Piperidines Using Heterogeneous Hydrogenation
por: Wagener, Tobias, et al.
Publicado: (2020)

Anticancer Activity of Novel Difluorinated Curcumin Analog and Its Inclusion Complex with 2-Hydroxypropyl-β-Cyclodextrin against Pancreatic Cancer
por: Bhattacharyya, Sangita, et al.
Publicado: (2023)

Crystal structure of 2,6-bis(2,5-dimethoxyphenyl)-3,5-dimethylpiperidin-4-one
por: Park, Dong Ho, et al.
Publicado: (2014)

Enhanced immunosuppressive effects of 3,5-bis[4(diethoxymethyl)benzylidene]-1-methyl-piperidin-4-one, an α, β-unsaturated carbonyl-based compound as PLGA-b-PEG nanoparticles
por: Arshad, Laiba, et al.
Publicado: (2019)

(E)-2-[4-(Piperidin-1-yl)benzylidene]-2,3-dihydro-1H-inden-1-one
por: Ali, Mohamed Ashraf, et al.
Publicado: (2010)

Intramolecular tetrazine-acryloyl cycloaddition: chemistry and applications
por: Hamsath, Akil, et al.
Publicado: (2022)

Prins fluorination cyclisations: Preparation of 4-fluoro-pyran and -piperidine heterocycles
por: Launay, Guillaume G, et al.
Publicado: (2010)

Understanding the Conformational Behavior of Fluorinated Piperidines: The Origin of the Axial‐F Preference
por: Nairoukh, Zackaria, et al.
Publicado: (2020)

Imidazole Analogs of Vascular-Disrupting Combretastatin A-4 with Pleiotropic Efficacy against Resistant Colorectal Cancer Models
por: Reipsch, Franziska, et al.
Publicado: (2021)

Poly[(N-acryloyl glycinamide)-co-(N-acryloyl l-alaninamide)] and Their Ability to Form Thermo-Responsive Hydrogels for Sustained Drug Delivery
por: Boustta, Mahfoud, et al.
Publicado: (2019)

Crystal structure of ethyl 5-[3-(dimethylamino)acryloyl]-2-{[(dimethylamino)methylidene]amino}-4-methylthiophene-3-carboxylate
por: Krishnamurthy, M. S., et al.
Publicado: (2015)

5-Chloro-5′′-[4-(dimethylamino)benzylidene]-4′-[4-(dimethylamino)phenyl]-1′,1′′-dimethyldispiro[indoline-3,2′-pyrrolidine-3′,3′′-piperidine]-2,4′′-dione
por: Farag, I. S. Ahmed, et al.
Publicado: (2013)

2‐Amino‐4‐aryl‐5‐oxo‐4,5‐dihydropyrano[3,2‐c]chromene‐3‐carbonitriles with Microtubule‐Disruptive, Centrosome‐Declustering, and Antiangiogenic Effects in vitro and in vivo
por: Köhler, Leonhard H. F., et al.
Publicado: (2022)

Antiparasitic Activity of Fluorophenyl-Substituted Pyrimido[1,2-a]benzimidazoles
por: Nasr, Ibrahim S. Al, et al.
Publicado: (2023)

(3E,5E)-3,5-Dibenzylidene-1-[3-(piperidin-1-yl)propanoyl]piperidin-4-one
por: Kia, Yalda, et al.
Publicado: (2011)

r-2,c-6-Diphenylpiperidine
por: Maheshwaran, V., et al.
Publicado: (2013)

Crystal structure and Hirshfeld surface analysis of (E)-N′-[4-(piperidin-1-yl)benzylidene]arylsulfonohydrazides
por: Pai, Nikhila, et al.
Publicado: (2018)

Acute respiratory distress syndrome due to inhalation of acryloyl chloride
por: Shima, Takafumi, et al.
Publicado: (2022)

(3E,5E)-3,5-Bis(4-allyloxybenzylidene)-1-benzylpiperidin-4-one
por: Karthikeyan, N. S., et al.
Publicado: (2009)

1-Benzyl-3,5-bis(4-chlorobenzylidene)piperidin-4-one
por: Nesterov, Volodymyr V., et al.
Publicado: (2011)

3,5-Bis(4-chlorobenzylidene)-1-methylpiperidin-4-one
por: Nesterov, Volodymyr V., et al.
Publicado: (2011)

3-Ethyl-cis-2,6-diphenylpiperidine
por: Maheshwaran, V., et al.
Publicado: (2013)

4-{[4-(Dimethylamino)benzylidene]amino}benzenesulfonamide
por: Durgun, Mustafa, et al.
Publicado: (2014)

N-[4-(Dimethylamino)benzylidene]-4-methylaniline
por: Balachandar, R. K., et al.
Publicado: (2013)

1-Dichloroacetyl-t-3-isopropyl-r-2,c-6-diphenylpiperidin-4-one
por: Sugumar, P., et al.
Publicado: (2013)

Crystal structures of 3,5-bis[(E)-3-hydroxybenzylidene]-1-methylpiperidin-4-one and 3,5-bis[(E)-2-chlorobenzylidene]-1-methylpiperidin-4-one
por: Eryanti, Yum, et al.
Publicado: (2015)

(3E,5E)-3,5-Bis(4-methylbenzylidene)-1-[3-(piperidin-1-yl)propanoyl]piperidin-4-one
por: Kia, Yalda, et al.
Publicado: (2012)

3,3-Dimethyl-cis-2,6-di-p-tolylpiperidin-4-one
por: Gayathri, P., et al.
Publicado: (2009)

(3E,5E)-3,5-Dibenzylidene-1-phenethylpiperidin-4-one
por: Ali, Mohamed Ashraf, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_m9p2r23u2m492ecjr2m8fpqse5