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Mpox Incidence and Vaccine Uptake in Men Who Have Sex with Men and Are Living with HIV in Denmark

(1) Background: Here, we investigate the incidence of mpox and factors associated with vaccine uptake in mainly well-treated men who have sex with men and are living with HIV (MSMWH). (2) Methods: This study included 727 MSMWH from the Copenhagen co-morbidity in HIV infection (COCOMO) study from 1 M...

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Autores principales: Svartstein, Anne-Sophie Winther, Knudsen, Andreas Dehlbæk, Heidari, Safura-Luise, Heftdal, Line Dam, Gelpi, Marco, Benfield, Thomas, Nielsen, Susanne Dam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10385255/
https://www.ncbi.nlm.nih.gov/pubmed/37514983
http://dx.doi.org/10.3390/vaccines11071167
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author Svartstein, Anne-Sophie Winther
Knudsen, Andreas Dehlbæk
Heidari, Safura-Luise
Heftdal, Line Dam
Gelpi, Marco
Benfield, Thomas
Nielsen, Susanne Dam
author_facet Svartstein, Anne-Sophie Winther
Knudsen, Andreas Dehlbæk
Heidari, Safura-Luise
Heftdal, Line Dam
Gelpi, Marco
Benfield, Thomas
Nielsen, Susanne Dam
author_sort Svartstein, Anne-Sophie Winther
collection PubMed
description (1) Background: Here, we investigate the incidence of mpox and factors associated with vaccine uptake in mainly well-treated men who have sex with men and are living with HIV (MSMWH). (2) Methods: This study included 727 MSMWH from the Copenhagen co-morbidity in HIV infection (COCOMO) study from 1 May to 31 October 2022. Mpox infection and vaccination status were obtained from the Danish Microbiology Database and The Danish Vaccination Register. Vaccination willingness was assessed through an online survey. (3) Results: At a median follow-up of 180 days, 13 (1.8%) participants had laboratory-confirmed mpox infections. Furthermore, 238 (32.7%) had received the mpox vaccine. A sexually transmitted disease (STD) in the preceding two years was associated with a higher risk of mpox infection (hazard ratio 7.1; 95% confidence interval (CI) [1.9–26.9]) and with higher odds of vaccination (adjusted odds ratio 3.1; 95% CI [2.2–4.6]). 401 (55.2%) participants responded to the survey. 228 (57.0%) reported very high vaccination willingness. The self-perceived risk of infection was associated with vaccine uptake. (4) Conclusions: The incidence of mpox was low. A prior STD was associated with both a higher risk of mpox infection and higher odds of vaccination. Despite high-risk sexual behavior and high vaccination willingness, a sizable fraction of participants had not been vaccinated.
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spelling pubmed-103852552023-07-30 Mpox Incidence and Vaccine Uptake in Men Who Have Sex with Men and Are Living with HIV in Denmark Svartstein, Anne-Sophie Winther Knudsen, Andreas Dehlbæk Heidari, Safura-Luise Heftdal, Line Dam Gelpi, Marco Benfield, Thomas Nielsen, Susanne Dam Vaccines (Basel) Article (1) Background: Here, we investigate the incidence of mpox and factors associated with vaccine uptake in mainly well-treated men who have sex with men and are living with HIV (MSMWH). (2) Methods: This study included 727 MSMWH from the Copenhagen co-morbidity in HIV infection (COCOMO) study from 1 May to 31 October 2022. Mpox infection and vaccination status were obtained from the Danish Microbiology Database and The Danish Vaccination Register. Vaccination willingness was assessed through an online survey. (3) Results: At a median follow-up of 180 days, 13 (1.8%) participants had laboratory-confirmed mpox infections. Furthermore, 238 (32.7%) had received the mpox vaccine. A sexually transmitted disease (STD) in the preceding two years was associated with a higher risk of mpox infection (hazard ratio 7.1; 95% confidence interval (CI) [1.9–26.9]) and with higher odds of vaccination (adjusted odds ratio 3.1; 95% CI [2.2–4.6]). 401 (55.2%) participants responded to the survey. 228 (57.0%) reported very high vaccination willingness. The self-perceived risk of infection was associated with vaccine uptake. (4) Conclusions: The incidence of mpox was low. A prior STD was associated with both a higher risk of mpox infection and higher odds of vaccination. Despite high-risk sexual behavior and high vaccination willingness, a sizable fraction of participants had not been vaccinated. MDPI 2023-06-27 /pmc/articles/PMC10385255/ /pubmed/37514983 http://dx.doi.org/10.3390/vaccines11071167 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Svartstein, Anne-Sophie Winther
Knudsen, Andreas Dehlbæk
Heidari, Safura-Luise
Heftdal, Line Dam
Gelpi, Marco
Benfield, Thomas
Nielsen, Susanne Dam
Mpox Incidence and Vaccine Uptake in Men Who Have Sex with Men and Are Living with HIV in Denmark
title Mpox Incidence and Vaccine Uptake in Men Who Have Sex with Men and Are Living with HIV in Denmark
title_full Mpox Incidence and Vaccine Uptake in Men Who Have Sex with Men and Are Living with HIV in Denmark
title_fullStr Mpox Incidence and Vaccine Uptake in Men Who Have Sex with Men and Are Living with HIV in Denmark
title_full_unstemmed Mpox Incidence and Vaccine Uptake in Men Who Have Sex with Men and Are Living with HIV in Denmark
title_short Mpox Incidence and Vaccine Uptake in Men Who Have Sex with Men and Are Living with HIV in Denmark
title_sort mpox incidence and vaccine uptake in men who have sex with men and are living with hiv in denmark
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10385255/
https://www.ncbi.nlm.nih.gov/pubmed/37514983
http://dx.doi.org/10.3390/vaccines11071167
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