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White Matter Metabolite Ratios Predict Cognitive Outcome in Pediatric Traumatic Brain Injury
The prognostic ability of global white matter and gray matter metabolite ratios following pediatric traumatic brain injury (TBI) and their relationship to 12-month neuropsychological assessments of intelligence quotient (IQ), attention, and memory is presented. Three-dimensional proton magnetic reso...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10385309/ https://www.ncbi.nlm.nih.gov/pubmed/37512485 http://dx.doi.org/10.3390/metabo13070778 |
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author | Berger, Luke Holshouser, Barbara Nichols, Joy G. Pivonka-Jones, Jamie Ashwal, Stephen Bartnik-Olson, Brenda |
author_facet | Berger, Luke Holshouser, Barbara Nichols, Joy G. Pivonka-Jones, Jamie Ashwal, Stephen Bartnik-Olson, Brenda |
author_sort | Berger, Luke |
collection | PubMed |
description | The prognostic ability of global white matter and gray matter metabolite ratios following pediatric traumatic brain injury (TBI) and their relationship to 12-month neuropsychological assessments of intelligence quotient (IQ), attention, and memory is presented. Three-dimensional proton magnetic resonance spectroscopic imaging (MRSI) in pediatric subjects with complicated mild (cMild), moderate, and severe TBI was acquired acutely (6–18 days) and 12 months post-injury and compared to age-matched typically developing adolescents. A global linear regression model, co-registering MRSI metabolite maps with 3D high-resolution magnetic resonance images, was used to identify longitudinal white matter and gray matter metabolite ratio changes. Acutely, gray matter NAA/Cr, white matter NAA/Cr, and white matter NAA/Cho ratios were significantly lower in TBI groups compared to controls. Gray matter NAA/Cho was reduced only in the severe TBI group. At 12 months, all metabolite ratios normalized to control levels in each of the TBI groups. Acute gray matter and white matter NAA ratios were significantly correlated to 12-month assessments of IQ, attention, and memory. These findings suggest that whole brain gray matter and white matter metabolite ratios reflect longitudinal changes in neuronal metabolism following TBI, which can be used to predict neuropsychological outcomes in pediatric subjects. |
format | Online Article Text |
id | pubmed-10385309 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103853092023-07-30 White Matter Metabolite Ratios Predict Cognitive Outcome in Pediatric Traumatic Brain Injury Berger, Luke Holshouser, Barbara Nichols, Joy G. Pivonka-Jones, Jamie Ashwal, Stephen Bartnik-Olson, Brenda Metabolites Article The prognostic ability of global white matter and gray matter metabolite ratios following pediatric traumatic brain injury (TBI) and their relationship to 12-month neuropsychological assessments of intelligence quotient (IQ), attention, and memory is presented. Three-dimensional proton magnetic resonance spectroscopic imaging (MRSI) in pediatric subjects with complicated mild (cMild), moderate, and severe TBI was acquired acutely (6–18 days) and 12 months post-injury and compared to age-matched typically developing adolescents. A global linear regression model, co-registering MRSI metabolite maps with 3D high-resolution magnetic resonance images, was used to identify longitudinal white matter and gray matter metabolite ratio changes. Acutely, gray matter NAA/Cr, white matter NAA/Cr, and white matter NAA/Cho ratios were significantly lower in TBI groups compared to controls. Gray matter NAA/Cho was reduced only in the severe TBI group. At 12 months, all metabolite ratios normalized to control levels in each of the TBI groups. Acute gray matter and white matter NAA ratios were significantly correlated to 12-month assessments of IQ, attention, and memory. These findings suggest that whole brain gray matter and white matter metabolite ratios reflect longitudinal changes in neuronal metabolism following TBI, which can be used to predict neuropsychological outcomes in pediatric subjects. MDPI 2023-06-22 /pmc/articles/PMC10385309/ /pubmed/37512485 http://dx.doi.org/10.3390/metabo13070778 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Berger, Luke Holshouser, Barbara Nichols, Joy G. Pivonka-Jones, Jamie Ashwal, Stephen Bartnik-Olson, Brenda White Matter Metabolite Ratios Predict Cognitive Outcome in Pediatric Traumatic Brain Injury |
title | White Matter Metabolite Ratios Predict Cognitive Outcome in Pediatric Traumatic Brain Injury |
title_full | White Matter Metabolite Ratios Predict Cognitive Outcome in Pediatric Traumatic Brain Injury |
title_fullStr | White Matter Metabolite Ratios Predict Cognitive Outcome in Pediatric Traumatic Brain Injury |
title_full_unstemmed | White Matter Metabolite Ratios Predict Cognitive Outcome in Pediatric Traumatic Brain Injury |
title_short | White Matter Metabolite Ratios Predict Cognitive Outcome in Pediatric Traumatic Brain Injury |
title_sort | white matter metabolite ratios predict cognitive outcome in pediatric traumatic brain injury |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10385309/ https://www.ncbi.nlm.nih.gov/pubmed/37512485 http://dx.doi.org/10.3390/metabo13070778 |
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