Solid-Phase Synthesis of 2-Benzothiazolyl and 2-(Aminophenyl)benzothiazolyl Amino Acids and Peptides

2-benzothiazoles and 2-(aminophenyl)benzothiazoles represent biologically interesting heterocycles with high pharmacological activity. The combination of these heterocycles with amino acids and peptides is of special interest, as such structures combine the advantages of amino acids and peptides wit...

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Detalles Bibliográficos
Autores principales: Mourtas, Spyridon, Athanasopoulos, Vasileios, Gatos, Dimitrios, Barlos, Kleomenis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10385376/
https://www.ncbi.nlm.nih.gov/pubmed/37513284
http://dx.doi.org/10.3390/molecules28145412
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author Mourtas, Spyridon
Athanasopoulos, Vasileios
Gatos, Dimitrios
Barlos, Kleomenis
author_facet Mourtas, Spyridon
Athanasopoulos, Vasileios
Gatos, Dimitrios
Barlos, Kleomenis
author_sort Mourtas, Spyridon
collection PubMed
description 2-benzothiazoles and 2-(aminophenyl)benzothiazoles represent biologically interesting heterocycles with high pharmacological activity. The combination of these heterocycles with amino acids and peptides is of special interest, as such structures combine the advantages of amino acids and peptides with the advantages of the 2-benzothiazolyl and 2-(aminophenyl)benzothiazolyl pharmacophore group. In this work, we developed an easy and efficient method for the solid-phase synthesis of 2-benzothiazolyl (BTH) and 2-(aminophenyl)benzothiazolyl (AP-BTH) C-terminal modified amino acids and peptides with high chiral purity.
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spelling pubmed-103853762023-07-30 Solid-Phase Synthesis of 2-Benzothiazolyl and 2-(Aminophenyl)benzothiazolyl Amino Acids and Peptides Mourtas, Spyridon Athanasopoulos, Vasileios Gatos, Dimitrios Barlos, Kleomenis Molecules Article 2-benzothiazoles and 2-(aminophenyl)benzothiazoles represent biologically interesting heterocycles with high pharmacological activity. The combination of these heterocycles with amino acids and peptides is of special interest, as such structures combine the advantages of amino acids and peptides with the advantages of the 2-benzothiazolyl and 2-(aminophenyl)benzothiazolyl pharmacophore group. In this work, we developed an easy and efficient method for the solid-phase synthesis of 2-benzothiazolyl (BTH) and 2-(aminophenyl)benzothiazolyl (AP-BTH) C-terminal modified amino acids and peptides with high chiral purity. MDPI 2023-07-14 /pmc/articles/PMC10385376/ /pubmed/37513284 http://dx.doi.org/10.3390/molecules28145412 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mourtas, Spyridon
Athanasopoulos, Vasileios
Gatos, Dimitrios
Barlos, Kleomenis
Solid-Phase Synthesis of 2-Benzothiazolyl and 2-(Aminophenyl)benzothiazolyl Amino Acids and Peptides
title Solid-Phase Synthesis of 2-Benzothiazolyl and 2-(Aminophenyl)benzothiazolyl Amino Acids and Peptides
title_full Solid-Phase Synthesis of 2-Benzothiazolyl and 2-(Aminophenyl)benzothiazolyl Amino Acids and Peptides
title_fullStr Solid-Phase Synthesis of 2-Benzothiazolyl and 2-(Aminophenyl)benzothiazolyl Amino Acids and Peptides
title_full_unstemmed Solid-Phase Synthesis of 2-Benzothiazolyl and 2-(Aminophenyl)benzothiazolyl Amino Acids and Peptides
title_short Solid-Phase Synthesis of 2-Benzothiazolyl and 2-(Aminophenyl)benzothiazolyl Amino Acids and Peptides
title_sort solid-phase synthesis of 2-benzothiazolyl and 2-(aminophenyl)benzothiazolyl amino acids and peptides
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10385376/
https://www.ncbi.nlm.nih.gov/pubmed/37513284
http://dx.doi.org/10.3390/molecules28145412
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