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Dietary Acid Load and Cancer Risk: A Review of the Uruguayan Experience

Dietary acid load (DAL) is recognized as a risk factor for several chronic disorders, including obesity, diabetes, and osteoporosis. Recent evidence suggests that an elevated DAL, as measured by the validated potential renal acid load (PRAL) and net endogenous acid production (NEAP) scores, could al...

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Autores principales: Ronco, Alvaro Luis, Storz, Maximilian Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10385454/
https://www.ncbi.nlm.nih.gov/pubmed/37513516
http://dx.doi.org/10.3390/nu15143098
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author Ronco, Alvaro Luis
Storz, Maximilian Andreas
author_facet Ronco, Alvaro Luis
Storz, Maximilian Andreas
author_sort Ronco, Alvaro Luis
collection PubMed
description Dietary acid load (DAL) is recognized as a risk factor for several chronic disorders, including obesity, diabetes, and osteoporosis. Recent evidence suggests that an elevated DAL, as measured by the validated potential renal acid load (PRAL) and net endogenous acid production (NEAP) scores, could also increase the risk for several cancers. This narrative review summarizes the potential role of DAL in Uruguayan cancer patients and outlines the potentially involved pathophysiological pathways that mediate the role of DAL in both cancer development and growth. Although Uruguay is a developing country, its average diet is a heavily meat-based Western one, translating into a supraphysiological acid burden from diet. In recent years, we have published epidemiologic evidence based on ten case-control studies involving 3736 cancer cases and 9534 hospital-based controls. Odds ratios and 95% confidence intervals were estimated for each interest variable to analyze the association between the exposure levels of DAL scores and cancer, calculated by unconditional logistic regression. In a majority of the cases, the highest DAL scores tended to double the cancer risk as compared to the lowest category. We also found high risks for methionine intake, an acidifying amino acid found in higher concentrations in animal-based foods, which may increase cancer risks at least by a joint action based on the pH and the proliferation enhancing properties of the amino acid itself.
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spelling pubmed-103854542023-07-30 Dietary Acid Load and Cancer Risk: A Review of the Uruguayan Experience Ronco, Alvaro Luis Storz, Maximilian Andreas Nutrients Review Dietary acid load (DAL) is recognized as a risk factor for several chronic disorders, including obesity, diabetes, and osteoporosis. Recent evidence suggests that an elevated DAL, as measured by the validated potential renal acid load (PRAL) and net endogenous acid production (NEAP) scores, could also increase the risk for several cancers. This narrative review summarizes the potential role of DAL in Uruguayan cancer patients and outlines the potentially involved pathophysiological pathways that mediate the role of DAL in both cancer development and growth. Although Uruguay is a developing country, its average diet is a heavily meat-based Western one, translating into a supraphysiological acid burden from diet. In recent years, we have published epidemiologic evidence based on ten case-control studies involving 3736 cancer cases and 9534 hospital-based controls. Odds ratios and 95% confidence intervals were estimated for each interest variable to analyze the association between the exposure levels of DAL scores and cancer, calculated by unconditional logistic regression. In a majority of the cases, the highest DAL scores tended to double the cancer risk as compared to the lowest category. We also found high risks for methionine intake, an acidifying amino acid found in higher concentrations in animal-based foods, which may increase cancer risks at least by a joint action based on the pH and the proliferation enhancing properties of the amino acid itself. MDPI 2023-07-11 /pmc/articles/PMC10385454/ /pubmed/37513516 http://dx.doi.org/10.3390/nu15143098 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ronco, Alvaro Luis
Storz, Maximilian Andreas
Dietary Acid Load and Cancer Risk: A Review of the Uruguayan Experience
title Dietary Acid Load and Cancer Risk: A Review of the Uruguayan Experience
title_full Dietary Acid Load and Cancer Risk: A Review of the Uruguayan Experience
title_fullStr Dietary Acid Load and Cancer Risk: A Review of the Uruguayan Experience
title_full_unstemmed Dietary Acid Load and Cancer Risk: A Review of the Uruguayan Experience
title_short Dietary Acid Load and Cancer Risk: A Review of the Uruguayan Experience
title_sort dietary acid load and cancer risk: a review of the uruguayan experience
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10385454/
https://www.ncbi.nlm.nih.gov/pubmed/37513516
http://dx.doi.org/10.3390/nu15143098
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