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A Recombinant Oncolytic Pseudorabies Virus Expressing Interleukin-18, Interferon-Gamma and PH20 Genes Promotes Systemic Antitumor Immunity

Pseudorabies virus (PRV) is considered to be a promising oncolytic virus that has potential as a cancer gene therapy drug. In this study, PRV-DCD-1-70 was used as a vector to carry exogenous genes IL-18, IFN-γ and PH20 to construct novel recombinant PRV, rPRV-PH20 and rPRV-IL-18-γ-PH20, and their tu...

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Detalles Bibliográficos
Autores principales:	Han, Xiaohui, Sun, Jingshuai, Lv, Xiaocheng, Tang, Xiaoyu, Zheng, Yubin, Ma, Jinyun, Sun, Yuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10385555/ https://www.ncbi.nlm.nih.gov/pubmed/37513021 http://dx.doi.org/10.3390/microorganisms11071850

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