Mechanistic Elucidation of Activation/Deactivation Signal Transduction within Neurotensin Receptor 1 Triggered by ‘Driver Chemical Groups’ of Modulators: A Comparative Molecular Dynamics Simulation

Small-molecule modulators of neurotensin receptor 1 (NTSR1), a class A G-protein-coupled receptor (GPCR), has emerged as promising therapeutic agent for psychiatric disorders and cancer. Interestingly, a chemical group substitution in NTSR1 modulators can launch different types of downstream regulat...

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Detalles Bibliográficos
Autores principales: Lu, Xun, Shi, Xinchao, Fan, Jigang, Li, Mingyu, Zhang, Yuxiang, Lu, Shaoyong, Xu, Guanghuan, Chen, Ziqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10385606/
https://www.ncbi.nlm.nih.gov/pubmed/37514186
http://dx.doi.org/10.3390/pharmaceutics15072000

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