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Safety and Protective Efficacy of a Candidate Vector-Based Vaccine for Bovine Tuberculosis
This study presents the results of a survey of the safety and protective efficacy of a candidate vector-based vaccine for bovine tuberculosis, using an influenza vector with the NS1 mutation and expressing M. bovis protective antigens ESAT-6 and TB10.4. We vaccinated Balb/c outbred mice two times at...
| Autores principales: | , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10385609/ https://www.ncbi.nlm.nih.gov/pubmed/37515015 http://dx.doi.org/10.3390/vaccines11071199 |
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| author | Abay, Zhandos Nurpeisova, Ainur Shorayeva, Kamshat Sadikaliyeva, Sandugash Yespembetov, Bolat Syrym, Nazym Sarmykova, Makhpal Jekebekov, Kuanysh Abitayev, Ruslan Tokkarina, Gaukhar Kalimolda, Elina Absatova, Zharkinay Moldagulova, Sabina Yoo, Han Sang Kassenov, Markhabat Zakarya, Kunsulu Abduraimov, Yergali |
| author_facet | Abay, Zhandos Nurpeisova, Ainur Shorayeva, Kamshat Sadikaliyeva, Sandugash Yespembetov, Bolat Syrym, Nazym Sarmykova, Makhpal Jekebekov, Kuanysh Abitayev, Ruslan Tokkarina, Gaukhar Kalimolda, Elina Absatova, Zharkinay Moldagulova, Sabina Yoo, Han Sang Kassenov, Markhabat Zakarya, Kunsulu Abduraimov, Yergali |
| author_sort | Abay, Zhandos |
| collection | PubMed |
| description | This study presents the results of a survey of the safety and protective efficacy of a candidate vector-based vaccine for bovine tuberculosis, using an influenza vector with the NS1 mutation and expressing M. bovis protective antigens ESAT-6 and TB10.4. We vaccinated Balb/c outbred mice two times at 21 days apart. Our experimental design includes mice immunised with the candidate vaccine with or without adjuvant 15% Montanide Gel. The candidate vaccine’s safety was determined by biometric analysis, and protective efficacy was assessed by bacteriological and histological experiments following a virulent M. bovis-8 strain challenge. Our data indicated that the adjuvant-free version of the vaccine ensured complete protection from the M. bovis-8 infection in mice. |
| format | Online Article Text |
| id | pubmed-10385609 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2023 |
| publisher | MDPI |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-103856092023-07-30 Safety and Protective Efficacy of a Candidate Vector-Based Vaccine for Bovine Tuberculosis Abay, Zhandos Nurpeisova, Ainur Shorayeva, Kamshat Sadikaliyeva, Sandugash Yespembetov, Bolat Syrym, Nazym Sarmykova, Makhpal Jekebekov, Kuanysh Abitayev, Ruslan Tokkarina, Gaukhar Kalimolda, Elina Absatova, Zharkinay Moldagulova, Sabina Yoo, Han Sang Kassenov, Markhabat Zakarya, Kunsulu Abduraimov, Yergali Vaccines (Basel) Article This study presents the results of a survey of the safety and protective efficacy of a candidate vector-based vaccine for bovine tuberculosis, using an influenza vector with the NS1 mutation and expressing M. bovis protective antigens ESAT-6 and TB10.4. We vaccinated Balb/c outbred mice two times at 21 days apart. Our experimental design includes mice immunised with the candidate vaccine with or without adjuvant 15% Montanide Gel. The candidate vaccine’s safety was determined by biometric analysis, and protective efficacy was assessed by bacteriological and histological experiments following a virulent M. bovis-8 strain challenge. Our data indicated that the adjuvant-free version of the vaccine ensured complete protection from the M. bovis-8 infection in mice. MDPI 2023-07-04 /pmc/articles/PMC10385609/ /pubmed/37515015 http://dx.doi.org/10.3390/vaccines11071199 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| spellingShingle | Article Abay, Zhandos Nurpeisova, Ainur Shorayeva, Kamshat Sadikaliyeva, Sandugash Yespembetov, Bolat Syrym, Nazym Sarmykova, Makhpal Jekebekov, Kuanysh Abitayev, Ruslan Tokkarina, Gaukhar Kalimolda, Elina Absatova, Zharkinay Moldagulova, Sabina Yoo, Han Sang Kassenov, Markhabat Zakarya, Kunsulu Abduraimov, Yergali Safety and Protective Efficacy of a Candidate Vector-Based Vaccine for Bovine Tuberculosis |
| title | Safety and Protective Efficacy of a Candidate Vector-Based Vaccine for Bovine Tuberculosis |
| title_full | Safety and Protective Efficacy of a Candidate Vector-Based Vaccine for Bovine Tuberculosis |
| title_fullStr | Safety and Protective Efficacy of a Candidate Vector-Based Vaccine for Bovine Tuberculosis |
| title_full_unstemmed | Safety and Protective Efficacy of a Candidate Vector-Based Vaccine for Bovine Tuberculosis |
| title_short | Safety and Protective Efficacy of a Candidate Vector-Based Vaccine for Bovine Tuberculosis |
| title_sort | safety and protective efficacy of a candidate vector-based vaccine for bovine tuberculosis |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10385609/ https://www.ncbi.nlm.nih.gov/pubmed/37515015 http://dx.doi.org/10.3390/vaccines11071199 |
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