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Electrochemical Sensor Based on the Hierarchical Carbon Nanocomposite for Highly Sensitive Ciprofloxacin Determination
A new voltammetry method for the highly sensitive antibacterial drug ciprofloxacin (CIP) is presented using glassy carbon electrodes modified with hierarchical electrospun carbon nanofibers with NiCo nanoparticles (eCNF/CNT/NiCo-GCE). The use of a modified glassy carbon electrode in the form of hier...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10385619/ https://www.ncbi.nlm.nih.gov/pubmed/37505048 http://dx.doi.org/10.3390/membranes13070682 |
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author | Smajdor, Joanna Paczosa-Bator, Beata Piech, Robert |
author_facet | Smajdor, Joanna Paczosa-Bator, Beata Piech, Robert |
author_sort | Smajdor, Joanna |
collection | PubMed |
description | A new voltammetry method for the highly sensitive antibacterial drug ciprofloxacin (CIP) is presented using glassy carbon electrodes modified with hierarchical electrospun carbon nanofibers with NiCo nanoparticles (eCNF/CNT/NiCo-GCE). The use of a modified glassy carbon electrode in the form of hierarchical electrospun carbon nanofibers with NiCo nanoparticles (eCNF/CNT/NiCo) led to an LOD value as low as 6.0 µmol L(−1) with a measurement sensitivity of 3.33 µA µmol L(−1). The described procedure was successfully applied for CIP determination in samples with complex matrices, such as urine or plasma, and also in pharmaceutical products and antibiotic discs with satisfactory recovery values ranging between 94–104%. The proposed electrode was characterised by great stability, with the possibility of use for about 4 weeks without any significant change in the CIP peak current. The repeatability of the CIP response on the eCNF/CNT/NiCo/GC is also very good; its value measured and expressed as RSD is equal to 2.4% for a CIP concentration of 0.025 µmol L(−1) (for 7 consecutive CIP voltammogram registrations). The procedure for electrode preparation is quick and simple and does not involve the use of expensive apparatus. |
format | Online Article Text |
id | pubmed-10385619 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103856192023-07-30 Electrochemical Sensor Based on the Hierarchical Carbon Nanocomposite for Highly Sensitive Ciprofloxacin Determination Smajdor, Joanna Paczosa-Bator, Beata Piech, Robert Membranes (Basel) Article A new voltammetry method for the highly sensitive antibacterial drug ciprofloxacin (CIP) is presented using glassy carbon electrodes modified with hierarchical electrospun carbon nanofibers with NiCo nanoparticles (eCNF/CNT/NiCo-GCE). The use of a modified glassy carbon electrode in the form of hierarchical electrospun carbon nanofibers with NiCo nanoparticles (eCNF/CNT/NiCo) led to an LOD value as low as 6.0 µmol L(−1) with a measurement sensitivity of 3.33 µA µmol L(−1). The described procedure was successfully applied for CIP determination in samples with complex matrices, such as urine or plasma, and also in pharmaceutical products and antibiotic discs with satisfactory recovery values ranging between 94–104%. The proposed electrode was characterised by great stability, with the possibility of use for about 4 weeks without any significant change in the CIP peak current. The repeatability of the CIP response on the eCNF/CNT/NiCo/GC is also very good; its value measured and expressed as RSD is equal to 2.4% for a CIP concentration of 0.025 µmol L(−1) (for 7 consecutive CIP voltammogram registrations). The procedure for electrode preparation is quick and simple and does not involve the use of expensive apparatus. MDPI 2023-07-21 /pmc/articles/PMC10385619/ /pubmed/37505048 http://dx.doi.org/10.3390/membranes13070682 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Smajdor, Joanna Paczosa-Bator, Beata Piech, Robert Electrochemical Sensor Based on the Hierarchical Carbon Nanocomposite for Highly Sensitive Ciprofloxacin Determination |
title | Electrochemical Sensor Based on the Hierarchical Carbon Nanocomposite for Highly Sensitive Ciprofloxacin Determination |
title_full | Electrochemical Sensor Based on the Hierarchical Carbon Nanocomposite for Highly Sensitive Ciprofloxacin Determination |
title_fullStr | Electrochemical Sensor Based on the Hierarchical Carbon Nanocomposite for Highly Sensitive Ciprofloxacin Determination |
title_full_unstemmed | Electrochemical Sensor Based on the Hierarchical Carbon Nanocomposite for Highly Sensitive Ciprofloxacin Determination |
title_short | Electrochemical Sensor Based on the Hierarchical Carbon Nanocomposite for Highly Sensitive Ciprofloxacin Determination |
title_sort | electrochemical sensor based on the hierarchical carbon nanocomposite for highly sensitive ciprofloxacin determination |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10385619/ https://www.ncbi.nlm.nih.gov/pubmed/37505048 http://dx.doi.org/10.3390/membranes13070682 |
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