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Droplet-Based Microfluidics: Applications in Pharmaceuticals

Droplet-based microfluidics offer great opportunities for applications in various fields, such as diagnostics, food sciences, and drug discovery. A droplet provides an isolated environment for performing a single reaction within a microscale-volume sample, allowing for a fast reaction with a high se...

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Autores principales: Trinh, Thi Ngoc Diep, Do, Hoang Dang Khoa, Nam, Nguyen Nhat, Dan, Thach Thi, Trinh, Kieu The Loan, Lee, Nae Yoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10385691/
https://www.ncbi.nlm.nih.gov/pubmed/37513850
http://dx.doi.org/10.3390/ph16070937
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author Trinh, Thi Ngoc Diep
Do, Hoang Dang Khoa
Nam, Nguyen Nhat
Dan, Thach Thi
Trinh, Kieu The Loan
Lee, Nae Yoon
author_facet Trinh, Thi Ngoc Diep
Do, Hoang Dang Khoa
Nam, Nguyen Nhat
Dan, Thach Thi
Trinh, Kieu The Loan
Lee, Nae Yoon
author_sort Trinh, Thi Ngoc Diep
collection PubMed
description Droplet-based microfluidics offer great opportunities for applications in various fields, such as diagnostics, food sciences, and drug discovery. A droplet provides an isolated environment for performing a single reaction within a microscale-volume sample, allowing for a fast reaction with a high sensitivity, high throughput, and low risk of cross-contamination. Owing to several remarkable features, droplet-based microfluidic techniques have been intensively studied. In this review, we discuss the impact of droplet microfluidics, particularly focusing on drug screening and development. In addition, we surveyed various methods of device fabrication and droplet generation/manipulation. We further highlight some promising studies covering drug synthesis and delivery that were updated within the last 5 years. This review provides researchers with a quick guide that includes the most up-to-date and relevant information on the latest scientific findings on the development of droplet-based microfluidics in the pharmaceutical field.
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spelling pubmed-103856912023-07-30 Droplet-Based Microfluidics: Applications in Pharmaceuticals Trinh, Thi Ngoc Diep Do, Hoang Dang Khoa Nam, Nguyen Nhat Dan, Thach Thi Trinh, Kieu The Loan Lee, Nae Yoon Pharmaceuticals (Basel) Review Droplet-based microfluidics offer great opportunities for applications in various fields, such as diagnostics, food sciences, and drug discovery. A droplet provides an isolated environment for performing a single reaction within a microscale-volume sample, allowing for a fast reaction with a high sensitivity, high throughput, and low risk of cross-contamination. Owing to several remarkable features, droplet-based microfluidic techniques have been intensively studied. In this review, we discuss the impact of droplet microfluidics, particularly focusing on drug screening and development. In addition, we surveyed various methods of device fabrication and droplet generation/manipulation. We further highlight some promising studies covering drug synthesis and delivery that were updated within the last 5 years. This review provides researchers with a quick guide that includes the most up-to-date and relevant information on the latest scientific findings on the development of droplet-based microfluidics in the pharmaceutical field. MDPI 2023-06-28 /pmc/articles/PMC10385691/ /pubmed/37513850 http://dx.doi.org/10.3390/ph16070937 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Trinh, Thi Ngoc Diep
Do, Hoang Dang Khoa
Nam, Nguyen Nhat
Dan, Thach Thi
Trinh, Kieu The Loan
Lee, Nae Yoon
Droplet-Based Microfluidics: Applications in Pharmaceuticals
title Droplet-Based Microfluidics: Applications in Pharmaceuticals
title_full Droplet-Based Microfluidics: Applications in Pharmaceuticals
title_fullStr Droplet-Based Microfluidics: Applications in Pharmaceuticals
title_full_unstemmed Droplet-Based Microfluidics: Applications in Pharmaceuticals
title_short Droplet-Based Microfluidics: Applications in Pharmaceuticals
title_sort droplet-based microfluidics: applications in pharmaceuticals
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10385691/
https://www.ncbi.nlm.nih.gov/pubmed/37513850
http://dx.doi.org/10.3390/ph16070937
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