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Droplet-Based Microfluidics: Applications in Pharmaceuticals
Droplet-based microfluidics offer great opportunities for applications in various fields, such as diagnostics, food sciences, and drug discovery. A droplet provides an isolated environment for performing a single reaction within a microscale-volume sample, allowing for a fast reaction with a high se...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10385691/ https://www.ncbi.nlm.nih.gov/pubmed/37513850 http://dx.doi.org/10.3390/ph16070937 |
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author | Trinh, Thi Ngoc Diep Do, Hoang Dang Khoa Nam, Nguyen Nhat Dan, Thach Thi Trinh, Kieu The Loan Lee, Nae Yoon |
author_facet | Trinh, Thi Ngoc Diep Do, Hoang Dang Khoa Nam, Nguyen Nhat Dan, Thach Thi Trinh, Kieu The Loan Lee, Nae Yoon |
author_sort | Trinh, Thi Ngoc Diep |
collection | PubMed |
description | Droplet-based microfluidics offer great opportunities for applications in various fields, such as diagnostics, food sciences, and drug discovery. A droplet provides an isolated environment for performing a single reaction within a microscale-volume sample, allowing for a fast reaction with a high sensitivity, high throughput, and low risk of cross-contamination. Owing to several remarkable features, droplet-based microfluidic techniques have been intensively studied. In this review, we discuss the impact of droplet microfluidics, particularly focusing on drug screening and development. In addition, we surveyed various methods of device fabrication and droplet generation/manipulation. We further highlight some promising studies covering drug synthesis and delivery that were updated within the last 5 years. This review provides researchers with a quick guide that includes the most up-to-date and relevant information on the latest scientific findings on the development of droplet-based microfluidics in the pharmaceutical field. |
format | Online Article Text |
id | pubmed-10385691 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103856912023-07-30 Droplet-Based Microfluidics: Applications in Pharmaceuticals Trinh, Thi Ngoc Diep Do, Hoang Dang Khoa Nam, Nguyen Nhat Dan, Thach Thi Trinh, Kieu The Loan Lee, Nae Yoon Pharmaceuticals (Basel) Review Droplet-based microfluidics offer great opportunities for applications in various fields, such as diagnostics, food sciences, and drug discovery. A droplet provides an isolated environment for performing a single reaction within a microscale-volume sample, allowing for a fast reaction with a high sensitivity, high throughput, and low risk of cross-contamination. Owing to several remarkable features, droplet-based microfluidic techniques have been intensively studied. In this review, we discuss the impact of droplet microfluidics, particularly focusing on drug screening and development. In addition, we surveyed various methods of device fabrication and droplet generation/manipulation. We further highlight some promising studies covering drug synthesis and delivery that were updated within the last 5 years. This review provides researchers with a quick guide that includes the most up-to-date and relevant information on the latest scientific findings on the development of droplet-based microfluidics in the pharmaceutical field. MDPI 2023-06-28 /pmc/articles/PMC10385691/ /pubmed/37513850 http://dx.doi.org/10.3390/ph16070937 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Trinh, Thi Ngoc Diep Do, Hoang Dang Khoa Nam, Nguyen Nhat Dan, Thach Thi Trinh, Kieu The Loan Lee, Nae Yoon Droplet-Based Microfluidics: Applications in Pharmaceuticals |
title | Droplet-Based Microfluidics: Applications in Pharmaceuticals |
title_full | Droplet-Based Microfluidics: Applications in Pharmaceuticals |
title_fullStr | Droplet-Based Microfluidics: Applications in Pharmaceuticals |
title_full_unstemmed | Droplet-Based Microfluidics: Applications in Pharmaceuticals |
title_short | Droplet-Based Microfluidics: Applications in Pharmaceuticals |
title_sort | droplet-based microfluidics: applications in pharmaceuticals |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10385691/ https://www.ncbi.nlm.nih.gov/pubmed/37513850 http://dx.doi.org/10.3390/ph16070937 |
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