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Dietary Supplementation of Aspirin Promotes Drosophila Defense against Viral Infection

Aspirin, also known as acetylsalicylic acid, is widely consumed as a pain reliever and an anti-inflammatory as well as anti-platelet agent. Recently, our studies using the animal model of Drosophila demonstrated that the dietary supplementation of aspirin renovates age-onset intestinal dysfunction a...

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Autores principales: Kong, Fanrui, Qadeer, Abdul, Xie, Yali, Jin, Yiheng, Li, Qingyang, Xiao, Yihua, She, Kan, Zheng, Xianrui, Li, Jiashu, Ji, Shanming, Zhu, Yangyang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10385701/
https://www.ncbi.nlm.nih.gov/pubmed/37513173
http://dx.doi.org/10.3390/molecules28145300
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author Kong, Fanrui
Qadeer, Abdul
Xie, Yali
Jin, Yiheng
Li, Qingyang
Xiao, Yihua
She, Kan
Zheng, Xianrui
Li, Jiashu
Ji, Shanming
Zhu, Yangyang
author_facet Kong, Fanrui
Qadeer, Abdul
Xie, Yali
Jin, Yiheng
Li, Qingyang
Xiao, Yihua
She, Kan
Zheng, Xianrui
Li, Jiashu
Ji, Shanming
Zhu, Yangyang
author_sort Kong, Fanrui
collection PubMed
description Aspirin, also known as acetylsalicylic acid, is widely consumed as a pain reliever and an anti-inflammatory as well as anti-platelet agent. Recently, our studies using the animal model of Drosophila demonstrated that the dietary supplementation of aspirin renovates age-onset intestinal dysfunction and delays organismal aging. Nevertheless, it remains probable that aspirin plays functional roles in other biological activities, for instance antiviral defense reactions. Intriguingly, we observed that the replications of several types of viruses were drastically antagonized in Drosophila macrophage-like S2 cells with the addition of aspirin. Further in vivo experimental approaches illustrate that adult flies consuming aspirin harbor higher resistances to viral infections with respect to flies without aspirin treatment. Mechanistically, aspirin positively contributes to the Drosophila antiviral defense largely through mediating the STING (stimulator of interferon genes) but not the IMD (immune deficiency) signaling pathway. Collectively, our studies uncover a novel biological function of aspirin in modulating Drosophila antiviral immunity and provide theoretical bases for exploring new antiviral treatments in clinical trials.
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spelling pubmed-103857012023-07-30 Dietary Supplementation of Aspirin Promotes Drosophila Defense against Viral Infection Kong, Fanrui Qadeer, Abdul Xie, Yali Jin, Yiheng Li, Qingyang Xiao, Yihua She, Kan Zheng, Xianrui Li, Jiashu Ji, Shanming Zhu, Yangyang Molecules Article Aspirin, also known as acetylsalicylic acid, is widely consumed as a pain reliever and an anti-inflammatory as well as anti-platelet agent. Recently, our studies using the animal model of Drosophila demonstrated that the dietary supplementation of aspirin renovates age-onset intestinal dysfunction and delays organismal aging. Nevertheless, it remains probable that aspirin plays functional roles in other biological activities, for instance antiviral defense reactions. Intriguingly, we observed that the replications of several types of viruses were drastically antagonized in Drosophila macrophage-like S2 cells with the addition of aspirin. Further in vivo experimental approaches illustrate that adult flies consuming aspirin harbor higher resistances to viral infections with respect to flies without aspirin treatment. Mechanistically, aspirin positively contributes to the Drosophila antiviral defense largely through mediating the STING (stimulator of interferon genes) but not the IMD (immune deficiency) signaling pathway. Collectively, our studies uncover a novel biological function of aspirin in modulating Drosophila antiviral immunity and provide theoretical bases for exploring new antiviral treatments in clinical trials. MDPI 2023-07-09 /pmc/articles/PMC10385701/ /pubmed/37513173 http://dx.doi.org/10.3390/molecules28145300 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kong, Fanrui
Qadeer, Abdul
Xie, Yali
Jin, Yiheng
Li, Qingyang
Xiao, Yihua
She, Kan
Zheng, Xianrui
Li, Jiashu
Ji, Shanming
Zhu, Yangyang
Dietary Supplementation of Aspirin Promotes Drosophila Defense against Viral Infection
title Dietary Supplementation of Aspirin Promotes Drosophila Defense against Viral Infection
title_full Dietary Supplementation of Aspirin Promotes Drosophila Defense against Viral Infection
title_fullStr Dietary Supplementation of Aspirin Promotes Drosophila Defense against Viral Infection
title_full_unstemmed Dietary Supplementation of Aspirin Promotes Drosophila Defense against Viral Infection
title_short Dietary Supplementation of Aspirin Promotes Drosophila Defense against Viral Infection
title_sort dietary supplementation of aspirin promotes drosophila defense against viral infection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10385701/
https://www.ncbi.nlm.nih.gov/pubmed/37513173
http://dx.doi.org/10.3390/molecules28145300
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