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Decreased perifoveal ganglion cell complex thickness - a first sign for macular damage in patients using hydroxychloroquine
Aim: To examine ganglion cell complex (GCC) thickness detected by optical coherence tomography (OCT) in patients using hydroxychloroquine (HCQ), without any structural and functional macular changes to evaluate the initial symptoms of macular toxicity for early diagnosis before clinical evaluation....
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Romanian Society of Ophthalmology
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10385708/ https://www.ncbi.nlm.nih.gov/pubmed/37522014 http://dx.doi.org/10.22336/rjo.2023.26 |
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author | Agcayazi, Sümeyye Burcu Elpeze Gurlu, Vuslat Alacamli, Goksu |
author_facet | Agcayazi, Sümeyye Burcu Elpeze Gurlu, Vuslat Alacamli, Goksu |
author_sort | Agcayazi, Sümeyye Burcu Elpeze |
collection | PubMed |
description | Aim: To examine ganglion cell complex (GCC) thickness detected by optical coherence tomography (OCT) in patients using hydroxychloroquine (HCQ), without any structural and functional macular changes to evaluate the initial symptoms of macular toxicity for early diagnosis before clinical evaluation. Methods: Eighty eyes of forty patients (Group 1) and forty eyes of twenty healthy volunteer persons (Group 2) were included in the study. Detailed ophthalmologic and mydriatic fundus examination were applied to all patients and volunteers (controls). Spectral domain OCT, visual field (VF) and color vision test were performed. Measurements of macula thickness, GCC thickness (involving nerve fiber layer, ganglion cell layer and inner plexiform layer) and peripapillary retinal nerve fiber layer (RNFL) were performed with OCT. Patients with retinal pigment epithelial changes, VF paracentral scotoma and defected color vision were excluded from the planned study. Results: Perifoveal GCC layer thickness in all quadrants was significantly thinner in group 1 compared to group 2 (p=0.017, p=0.001, p=0.019, p=0.001). The mean global inferior hemifield and nasal quadrant RNFL thickness were lower than in the control groups (p=0,012, p=0,009, p=0,005, respectively). Conclusion: Changes in the thickness of nerve fiber layer and ganglion cell layer detected by optical coherence tomography can be thought to be used as a diagnostic aid for the early diagnosis of hydroxychloroquine-toxic maculopathy Abbreviations: GCC = Ganglion cell complex, OCT = Optical coherence tomography, HCQ = Hydroxychloroquine, BCVA = Best-corrected visual acuity, IOP = Intraocular pressure, VF = Visual field, RNFL = Retinal nerve fiber layer, SD OCT = Spectral-domain optical coherence tomography, mfERG = Multifocal electroretinogram, FAF = Fundus autofluorescence, IS/ OS = Inner segment-outer segment junction, SITA = Swedish Interactive Threshold Algorithm, RA = Rheumatoid arthritis, SLE = Systemic lupus erythematosus, SS = Sjogren syndrome |
format | Online Article Text |
id | pubmed-10385708 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Romanian Society of Ophthalmology |
record_format | MEDLINE/PubMed |
spelling | pubmed-103857082023-07-30 Decreased perifoveal ganglion cell complex thickness - a first sign for macular damage in patients using hydroxychloroquine Agcayazi, Sümeyye Burcu Elpeze Gurlu, Vuslat Alacamli, Goksu Rom J Ophthalmol General Articles Aim: To examine ganglion cell complex (GCC) thickness detected by optical coherence tomography (OCT) in patients using hydroxychloroquine (HCQ), without any structural and functional macular changes to evaluate the initial symptoms of macular toxicity for early diagnosis before clinical evaluation. Methods: Eighty eyes of forty patients (Group 1) and forty eyes of twenty healthy volunteer persons (Group 2) were included in the study. Detailed ophthalmologic and mydriatic fundus examination were applied to all patients and volunteers (controls). Spectral domain OCT, visual field (VF) and color vision test were performed. Measurements of macula thickness, GCC thickness (involving nerve fiber layer, ganglion cell layer and inner plexiform layer) and peripapillary retinal nerve fiber layer (RNFL) were performed with OCT. Patients with retinal pigment epithelial changes, VF paracentral scotoma and defected color vision were excluded from the planned study. Results: Perifoveal GCC layer thickness in all quadrants was significantly thinner in group 1 compared to group 2 (p=0.017, p=0.001, p=0.019, p=0.001). The mean global inferior hemifield and nasal quadrant RNFL thickness were lower than in the control groups (p=0,012, p=0,009, p=0,005, respectively). Conclusion: Changes in the thickness of nerve fiber layer and ganglion cell layer detected by optical coherence tomography can be thought to be used as a diagnostic aid for the early diagnosis of hydroxychloroquine-toxic maculopathy Abbreviations: GCC = Ganglion cell complex, OCT = Optical coherence tomography, HCQ = Hydroxychloroquine, BCVA = Best-corrected visual acuity, IOP = Intraocular pressure, VF = Visual field, RNFL = Retinal nerve fiber layer, SD OCT = Spectral-domain optical coherence tomography, mfERG = Multifocal electroretinogram, FAF = Fundus autofluorescence, IS/ OS = Inner segment-outer segment junction, SITA = Swedish Interactive Threshold Algorithm, RA = Rheumatoid arthritis, SLE = Systemic lupus erythematosus, SS = Sjogren syndrome Romanian Society of Ophthalmology 2023 /pmc/articles/PMC10385708/ /pubmed/37522014 http://dx.doi.org/10.22336/rjo.2023.26 Text en #x00A9; The Authors.Romanian Society of Ophthalmology https://creativecommons.org/licenses/by/2.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | General Articles Agcayazi, Sümeyye Burcu Elpeze Gurlu, Vuslat Alacamli, Goksu Decreased perifoveal ganglion cell complex thickness - a first sign for macular damage in patients using hydroxychloroquine |
title | Decreased perifoveal ganglion cell complex thickness - a first sign for macular damage in patients using hydroxychloroquine
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title_full | Decreased perifoveal ganglion cell complex thickness - a first sign for macular damage in patients using hydroxychloroquine
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title_fullStr | Decreased perifoveal ganglion cell complex thickness - a first sign for macular damage in patients using hydroxychloroquine
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title_full_unstemmed | Decreased perifoveal ganglion cell complex thickness - a first sign for macular damage in patients using hydroxychloroquine
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title_short | Decreased perifoveal ganglion cell complex thickness - a first sign for macular damage in patients using hydroxychloroquine
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title_sort | decreased perifoveal ganglion cell complex thickness - a first sign for macular damage in patients using hydroxychloroquine |
topic | General Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10385708/ https://www.ncbi.nlm.nih.gov/pubmed/37522014 http://dx.doi.org/10.22336/rjo.2023.26 |
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