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A Role for Bottom-Up Synthetic Cells in the Internet of Bio-Nano Things?

The potential role of bottom-up Synthetic Cells (SCs) in the Internet of Bio-Nano Things (IoBNT) is discussed. In particular, this perspective paper focuses on the growing interest in networks of biological and/or artificial objects at the micro- and nanoscale (cells and subcellular parts, microelec...

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Autores principales: Stano, Pasquale, Gentili, Pier Luigi, Damiano, Luisa, Magarini, Maurizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10385758/
https://www.ncbi.nlm.nih.gov/pubmed/37513436
http://dx.doi.org/10.3390/molecules28145564
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author Stano, Pasquale
Gentili, Pier Luigi
Damiano, Luisa
Magarini, Maurizio
author_facet Stano, Pasquale
Gentili, Pier Luigi
Damiano, Luisa
Magarini, Maurizio
author_sort Stano, Pasquale
collection PubMed
description The potential role of bottom-up Synthetic Cells (SCs) in the Internet of Bio-Nano Things (IoBNT) is discussed. In particular, this perspective paper focuses on the growing interest in networks of biological and/or artificial objects at the micro- and nanoscale (cells and subcellular parts, microelectrodes, microvessels, etc.), whereby communication takes place in an unconventional manner, i.e., via chemical signaling. The resulting “molecular communication” (MC) scenario paves the way to the development of innovative technologies that have the potential to impact biotechnology, nanomedicine, and related fields. The scenario that relies on the interconnection of natural and artificial entities is briefly introduced, highlighting how Synthetic Biology (SB) plays a central role. SB allows the construction of various types of SCs that can be designed, tailored, and programmed according to specific predefined requirements. In particular, “bottom-up” SCs are briefly described by commenting on the principles of their design and fabrication and their features (in particular, the capacity to exchange chemicals with other SCs or with natural biological cells). Although bottom-up SCs still have low complexity and thus basic functionalities, here, we introduce their potential role in the IoBNT. This perspective paper aims to stimulate interest in and discussion on the presented topics. The article also includes commentaries on MC, semantic information, minimal cognition, wetware neuromorphic engineering, and chemical social robotics, with the specific potential they can bring to the IoBNT.
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spelling pubmed-103857582023-07-30 A Role for Bottom-Up Synthetic Cells in the Internet of Bio-Nano Things? Stano, Pasquale Gentili, Pier Luigi Damiano, Luisa Magarini, Maurizio Molecules Perspective The potential role of bottom-up Synthetic Cells (SCs) in the Internet of Bio-Nano Things (IoBNT) is discussed. In particular, this perspective paper focuses on the growing interest in networks of biological and/or artificial objects at the micro- and nanoscale (cells and subcellular parts, microelectrodes, microvessels, etc.), whereby communication takes place in an unconventional manner, i.e., via chemical signaling. The resulting “molecular communication” (MC) scenario paves the way to the development of innovative technologies that have the potential to impact biotechnology, nanomedicine, and related fields. The scenario that relies on the interconnection of natural and artificial entities is briefly introduced, highlighting how Synthetic Biology (SB) plays a central role. SB allows the construction of various types of SCs that can be designed, tailored, and programmed according to specific predefined requirements. In particular, “bottom-up” SCs are briefly described by commenting on the principles of their design and fabrication and their features (in particular, the capacity to exchange chemicals with other SCs or with natural biological cells). Although bottom-up SCs still have low complexity and thus basic functionalities, here, we introduce their potential role in the IoBNT. This perspective paper aims to stimulate interest in and discussion on the presented topics. The article also includes commentaries on MC, semantic information, minimal cognition, wetware neuromorphic engineering, and chemical social robotics, with the specific potential they can bring to the IoBNT. MDPI 2023-07-21 /pmc/articles/PMC10385758/ /pubmed/37513436 http://dx.doi.org/10.3390/molecules28145564 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Perspective
Stano, Pasquale
Gentili, Pier Luigi
Damiano, Luisa
Magarini, Maurizio
A Role for Bottom-Up Synthetic Cells in the Internet of Bio-Nano Things?
title A Role for Bottom-Up Synthetic Cells in the Internet of Bio-Nano Things?
title_full A Role for Bottom-Up Synthetic Cells in the Internet of Bio-Nano Things?
title_fullStr A Role for Bottom-Up Synthetic Cells in the Internet of Bio-Nano Things?
title_full_unstemmed A Role for Bottom-Up Synthetic Cells in the Internet of Bio-Nano Things?
title_short A Role for Bottom-Up Synthetic Cells in the Internet of Bio-Nano Things?
title_sort role for bottom-up synthetic cells in the internet of bio-nano things?
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10385758/
https://www.ncbi.nlm.nih.gov/pubmed/37513436
http://dx.doi.org/10.3390/molecules28145564
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