Antiproliferative and Tubulin-Destabilising Effects of 3-(Prop-1-en-2-yl)azetidin-2-Ones and Related Compounds in MCF-7 and MDA-MB-231 Breast Cancer Cells

A series of novel 3-(prop-1-en-2-yl)azetidin-2-one, 3-allylazetidin-2-one and 3-(buta-1,3-dien-1-yl)azetidin-2-one analogues of combretastatin A-4 (CA-4) were designed and synthesised as colchicine-binding site inhibitors (CBSI) in which the ethylene bridge of CA-4 was replaced with a β-lactam (2-az...

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Detalles Bibliográficos
Autores principales: Wang, Shu, Malebari, Azizah M., Greene, Thomas F., Kandwal, Shubhangi, Fayne, Darren, Nathwani, Seema M., Zisterer, Daniela M., Twamley, Brendan, O’Boyle, Niamh M., Meegan, Mary J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10385824/
https://www.ncbi.nlm.nih.gov/pubmed/37513912
http://dx.doi.org/10.3390/ph16071000

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