Evaluation of the Ability of PAMPA Membranes to Emulate Biological Processes through the Abraham Solvation Parameter Model

Two parallel artificial membrane permeability assay (PAMPA) systems intended for emulating skin permeability have been characterized through the solvation parameter model of Abraham using multilinear regression analysis. The coefficients of the obtained equations have been compared to the ones alrea...

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Autores principales: Soriano-Meseguer, Sara, Fuguet, Elisabet, Port, Adriana, Rosés, Martí
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10385989/
https://www.ncbi.nlm.nih.gov/pubmed/37505006
http://dx.doi.org/10.3390/membranes13070640
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author Soriano-Meseguer, Sara
Fuguet, Elisabet
Port, Adriana
Rosés, Martí
author_facet Soriano-Meseguer, Sara
Fuguet, Elisabet
Port, Adriana
Rosés, Martí
author_sort Soriano-Meseguer, Sara
collection PubMed
description Two parallel artificial membrane permeability assay (PAMPA) systems intended for emulating skin permeability have been characterized through the solvation parameter model of Abraham using multilinear regression analysis. The coefficients of the obtained equations have been compared to the ones already established for other PAMPA membranes using statistical tools. The results indicate that both skin membranes are similar to each other in their physicochemical properties. However, they are different from other PAMPA membranes (e.g., intestinal absorption and blood–brain PAMPAs), mainly in terms of hydrophobicity and hydrogen bonding properties. Next, all PAMPA membranes have been compared to relevant biological processes also characterized through the solvation parameter model. The results highlight that skin-PAMPA membranes are a very good choice to emulate skin permeability.
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spelling pubmed-103859892023-07-30 Evaluation of the Ability of PAMPA Membranes to Emulate Biological Processes through the Abraham Solvation Parameter Model Soriano-Meseguer, Sara Fuguet, Elisabet Port, Adriana Rosés, Martí Membranes (Basel) Article Two parallel artificial membrane permeability assay (PAMPA) systems intended for emulating skin permeability have been characterized through the solvation parameter model of Abraham using multilinear regression analysis. The coefficients of the obtained equations have been compared to the ones already established for other PAMPA membranes using statistical tools. The results indicate that both skin membranes are similar to each other in their physicochemical properties. However, they are different from other PAMPA membranes (e.g., intestinal absorption and blood–brain PAMPAs), mainly in terms of hydrophobicity and hydrogen bonding properties. Next, all PAMPA membranes have been compared to relevant biological processes also characterized through the solvation parameter model. The results highlight that skin-PAMPA membranes are a very good choice to emulate skin permeability. MDPI 2023-06-30 /pmc/articles/PMC10385989/ /pubmed/37505006 http://dx.doi.org/10.3390/membranes13070640 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Soriano-Meseguer, Sara
Fuguet, Elisabet
Port, Adriana
Rosés, Martí
Evaluation of the Ability of PAMPA Membranes to Emulate Biological Processes through the Abraham Solvation Parameter Model
title Evaluation of the Ability of PAMPA Membranes to Emulate Biological Processes through the Abraham Solvation Parameter Model
title_full Evaluation of the Ability of PAMPA Membranes to Emulate Biological Processes through the Abraham Solvation Parameter Model
title_fullStr Evaluation of the Ability of PAMPA Membranes to Emulate Biological Processes through the Abraham Solvation Parameter Model
title_full_unstemmed Evaluation of the Ability of PAMPA Membranes to Emulate Biological Processes through the Abraham Solvation Parameter Model
title_short Evaluation of the Ability of PAMPA Membranes to Emulate Biological Processes through the Abraham Solvation Parameter Model
title_sort evaluation of the ability of pampa membranes to emulate biological processes through the abraham solvation parameter model
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10385989/
https://www.ncbi.nlm.nih.gov/pubmed/37505006
http://dx.doi.org/10.3390/membranes13070640
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