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From Plants to Wound Dressing and Transdermal Delivery of Bioactive Compounds

Transdermal delivery devices and wound dressing materials are constantly improved and upgraded with the aim of enhancing their beneficial effects, biocompatibility, biodegradability, and cost effectiveness. Therefore, researchers in the field have shown an increasing interest in using natural compou...

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Detalles Bibliográficos
Autores principales: Isopencu, Gabriela Olimpia, Covaliu-Mierlă, Cristina-Ileana, Deleanu, Iuliana-Mihaela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10386126/
https://www.ncbi.nlm.nih.gov/pubmed/37514275
http://dx.doi.org/10.3390/plants12142661
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author Isopencu, Gabriela Olimpia
Covaliu-Mierlă, Cristina-Ileana
Deleanu, Iuliana-Mihaela
author_facet Isopencu, Gabriela Olimpia
Covaliu-Mierlă, Cristina-Ileana
Deleanu, Iuliana-Mihaela
author_sort Isopencu, Gabriela Olimpia
collection PubMed
description Transdermal delivery devices and wound dressing materials are constantly improved and upgraded with the aim of enhancing their beneficial effects, biocompatibility, biodegradability, and cost effectiveness. Therefore, researchers in the field have shown an increasing interest in using natural compounds as constituents for such systems. Plants, as an important source of so-called “natural products” with an enormous variety and structural diversity that still exceeds the capacity of present-day sciences to define or even discover them, have been part of medicine since ancient times. However, their benefits are just at the beginning of being fully exploited in modern dermal and transdermal delivery systems. Thus, plant-based primary compounds, with or without biological activity, contained in gums and mucilages, traditionally used as gelling and texturing agents in the food industry, are now being explored as valuable and cost-effective natural components in the biomedical field. Their biodegradability, biocompatibility, and non-toxicity compensate for local availability and compositional variations. Also, secondary metabolites, classified based on their chemical structure, are being intensively investigated for their wide pharmacological and toxicological effects. Their impact on medicine is highlighted in detail through the most recent reported studies. Innovative isolation and purification techniques, new drug delivery devices and systems, and advanced evaluation procedures are presented.
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spelling pubmed-103861262023-07-30 From Plants to Wound Dressing and Transdermal Delivery of Bioactive Compounds Isopencu, Gabriela Olimpia Covaliu-Mierlă, Cristina-Ileana Deleanu, Iuliana-Mihaela Plants (Basel) Review Transdermal delivery devices and wound dressing materials are constantly improved and upgraded with the aim of enhancing their beneficial effects, biocompatibility, biodegradability, and cost effectiveness. Therefore, researchers in the field have shown an increasing interest in using natural compounds as constituents for such systems. Plants, as an important source of so-called “natural products” with an enormous variety and structural diversity that still exceeds the capacity of present-day sciences to define or even discover them, have been part of medicine since ancient times. However, their benefits are just at the beginning of being fully exploited in modern dermal and transdermal delivery systems. Thus, plant-based primary compounds, with or without biological activity, contained in gums and mucilages, traditionally used as gelling and texturing agents in the food industry, are now being explored as valuable and cost-effective natural components in the biomedical field. Their biodegradability, biocompatibility, and non-toxicity compensate for local availability and compositional variations. Also, secondary metabolites, classified based on their chemical structure, are being intensively investigated for their wide pharmacological and toxicological effects. Their impact on medicine is highlighted in detail through the most recent reported studies. Innovative isolation and purification techniques, new drug delivery devices and systems, and advanced evaluation procedures are presented. MDPI 2023-07-16 /pmc/articles/PMC10386126/ /pubmed/37514275 http://dx.doi.org/10.3390/plants12142661 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Isopencu, Gabriela Olimpia
Covaliu-Mierlă, Cristina-Ileana
Deleanu, Iuliana-Mihaela
From Plants to Wound Dressing and Transdermal Delivery of Bioactive Compounds
title From Plants to Wound Dressing and Transdermal Delivery of Bioactive Compounds
title_full From Plants to Wound Dressing and Transdermal Delivery of Bioactive Compounds
title_fullStr From Plants to Wound Dressing and Transdermal Delivery of Bioactive Compounds
title_full_unstemmed From Plants to Wound Dressing and Transdermal Delivery of Bioactive Compounds
title_short From Plants to Wound Dressing and Transdermal Delivery of Bioactive Compounds
title_sort from plants to wound dressing and transdermal delivery of bioactive compounds
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10386126/
https://www.ncbi.nlm.nih.gov/pubmed/37514275
http://dx.doi.org/10.3390/plants12142661
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