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sFLT1, PlGF, the sFLT1/PlGF Ratio and Their Association with Pre-Eclampsia in Twin Pregnancies—A Review of the Literature

Twin pregnancies demonstrate a 2–3-fold higher chance of developing PE compared to singletons, and recent evidence has demonstrated that the sFLT1/PIGF ratio is strongly associated with PE, adverse pregnancy outcomes, as well as imminent deliveries due to PE complications. The primary objective of t...

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Autores principales: Sapantzoglou, Ioakeim, Rouvali, Angeliki, Koutras, Antonios, Chatziioannou, Maria Ioanna, Prokopakis, Ioannis, Fasoulakis, Zacharias, Zachariou, Eleftherios, Douligeris, Athanasios, Mortaki, Anastasia, Perros, Paraskevas, Ntounis, Thomas, Pergialiotis, Vasilios, Domali, Ekaterini, Athanasiou, Stavros, Daskalakis, George, Rodolakis, Alexandros, Panagopoulos, Periklis, Pappa, Kalliopi I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10386152/
https://www.ncbi.nlm.nih.gov/pubmed/37512044
http://dx.doi.org/10.3390/medicina59071232
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author Sapantzoglou, Ioakeim
Rouvali, Angeliki
Koutras, Antonios
Chatziioannou, Maria Ioanna
Prokopakis, Ioannis
Fasoulakis, Zacharias
Zachariou, Eleftherios
Douligeris, Athanasios
Mortaki, Anastasia
Perros, Paraskevas
Ntounis, Thomas
Pergialiotis, Vasilios
Domali, Ekaterini
Athanasiou, Stavros
Daskalakis, George
Rodolakis, Alexandros
Panagopoulos, Periklis
Pappa, Kalliopi I.
author_facet Sapantzoglou, Ioakeim
Rouvali, Angeliki
Koutras, Antonios
Chatziioannou, Maria Ioanna
Prokopakis, Ioannis
Fasoulakis, Zacharias
Zachariou, Eleftherios
Douligeris, Athanasios
Mortaki, Anastasia
Perros, Paraskevas
Ntounis, Thomas
Pergialiotis, Vasilios
Domali, Ekaterini
Athanasiou, Stavros
Daskalakis, George
Rodolakis, Alexandros
Panagopoulos, Periklis
Pappa, Kalliopi I.
author_sort Sapantzoglou, Ioakeim
collection PubMed
description Twin pregnancies demonstrate a 2–3-fold higher chance of developing PE compared to singletons, and recent evidence has demonstrated that the sFLT1/PIGF ratio is strongly associated with PE, adverse pregnancy outcomes, as well as imminent deliveries due to PE complications. The primary objective of this systematic review was to summarise the available data on the levels of sFLT1, PlGF and their ratios in twin pregnancies and to investigate their association with the development of PE, adverse pregnancy outcomes and the timing of the delivery. A systematic search of Ovid Embase, Web of Science, Science Direct, PubMed, Ovid Medline, Google Scholar and CINAHL was carried out. sFLT1 levels and the sFLT1/PIGF ratio appeared higher in twins compared to singleton pregnancies, especially in the third trimester, while PlGF levels appeared higher up until the third trimester, with their values showing no difference or being even lower than in singletons thereafter. The sFLT1/PIGF ratio has been reported to be an independent marker of adverse outcomes related to pre-eclampsia and is associated with the mean time until delivery in an inverse manner. Further research is required in order to establish the optimal sFLT1/PIGF cut-off values and to stratify the risk of adverse outcomes in twin pregnancies.
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spelling pubmed-103861522023-07-30 sFLT1, PlGF, the sFLT1/PlGF Ratio and Their Association with Pre-Eclampsia in Twin Pregnancies—A Review of the Literature Sapantzoglou, Ioakeim Rouvali, Angeliki Koutras, Antonios Chatziioannou, Maria Ioanna Prokopakis, Ioannis Fasoulakis, Zacharias Zachariou, Eleftherios Douligeris, Athanasios Mortaki, Anastasia Perros, Paraskevas Ntounis, Thomas Pergialiotis, Vasilios Domali, Ekaterini Athanasiou, Stavros Daskalakis, George Rodolakis, Alexandros Panagopoulos, Periklis Pappa, Kalliopi I. Medicina (Kaunas) Review Twin pregnancies demonstrate a 2–3-fold higher chance of developing PE compared to singletons, and recent evidence has demonstrated that the sFLT1/PIGF ratio is strongly associated with PE, adverse pregnancy outcomes, as well as imminent deliveries due to PE complications. The primary objective of this systematic review was to summarise the available data on the levels of sFLT1, PlGF and their ratios in twin pregnancies and to investigate their association with the development of PE, adverse pregnancy outcomes and the timing of the delivery. A systematic search of Ovid Embase, Web of Science, Science Direct, PubMed, Ovid Medline, Google Scholar and CINAHL was carried out. sFLT1 levels and the sFLT1/PIGF ratio appeared higher in twins compared to singleton pregnancies, especially in the third trimester, while PlGF levels appeared higher up until the third trimester, with their values showing no difference or being even lower than in singletons thereafter. The sFLT1/PIGF ratio has been reported to be an independent marker of adverse outcomes related to pre-eclampsia and is associated with the mean time until delivery in an inverse manner. Further research is required in order to establish the optimal sFLT1/PIGF cut-off values and to stratify the risk of adverse outcomes in twin pregnancies. MDPI 2023-06-30 /pmc/articles/PMC10386152/ /pubmed/37512044 http://dx.doi.org/10.3390/medicina59071232 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sapantzoglou, Ioakeim
Rouvali, Angeliki
Koutras, Antonios
Chatziioannou, Maria Ioanna
Prokopakis, Ioannis
Fasoulakis, Zacharias
Zachariou, Eleftherios
Douligeris, Athanasios
Mortaki, Anastasia
Perros, Paraskevas
Ntounis, Thomas
Pergialiotis, Vasilios
Domali, Ekaterini
Athanasiou, Stavros
Daskalakis, George
Rodolakis, Alexandros
Panagopoulos, Periklis
Pappa, Kalliopi I.
sFLT1, PlGF, the sFLT1/PlGF Ratio and Their Association with Pre-Eclampsia in Twin Pregnancies—A Review of the Literature
title sFLT1, PlGF, the sFLT1/PlGF Ratio and Their Association with Pre-Eclampsia in Twin Pregnancies—A Review of the Literature
title_full sFLT1, PlGF, the sFLT1/PlGF Ratio and Their Association with Pre-Eclampsia in Twin Pregnancies—A Review of the Literature
title_fullStr sFLT1, PlGF, the sFLT1/PlGF Ratio and Their Association with Pre-Eclampsia in Twin Pregnancies—A Review of the Literature
title_full_unstemmed sFLT1, PlGF, the sFLT1/PlGF Ratio and Their Association with Pre-Eclampsia in Twin Pregnancies—A Review of the Literature
title_short sFLT1, PlGF, the sFLT1/PlGF Ratio and Their Association with Pre-Eclampsia in Twin Pregnancies—A Review of the Literature
title_sort sflt1, plgf, the sflt1/plgf ratio and their association with pre-eclampsia in twin pregnancies—a review of the literature
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10386152/
https://www.ncbi.nlm.nih.gov/pubmed/37512044
http://dx.doi.org/10.3390/medicina59071232
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