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Visfatin and Retinol Binding Protein-4 in Young-Onset Type 2 Diabetes Mellitus
Background and Objectives: The prevalence of type 2 diabetes mellitus in adolescents has increased rapidly in recent decades. However, the role of adipokines on pathophysiology in young-onset type 2 diabetes mellitus (YDM) is not clear. In this article, we explored the relationships between the adip...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10386173/ https://www.ncbi.nlm.nih.gov/pubmed/37512089 http://dx.doi.org/10.3390/medicina59071278 |
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author | Huang, Ya-Li Chen, Yen-Lin Lin, Jiunn-Diann Pei, Dee Pitrone, Pietro Chen, Jin-Shuen Wu, Chung-Ze |
author_facet | Huang, Ya-Li Chen, Yen-Lin Lin, Jiunn-Diann Pei, Dee Pitrone, Pietro Chen, Jin-Shuen Wu, Chung-Ze |
author_sort | Huang, Ya-Li |
collection | PubMed |
description | Background and Objectives: The prevalence of type 2 diabetes mellitus in adolescents has increased rapidly in recent decades. However, the role of adipokines on pathophysiology in young-onset type 2 diabetes mellitus (YDM) is not clear. In this article, we explored the relationships between the adipokines (visfatin and retinol binding protein 4 (RBP4)) and metabolic syndrome (MetS) components in both YDM and late-onset type 2 diabetes mellitus (ODM). Materials and Methods: There were 36 patients with YDM (23.6 ± 4.8 years) and 36 patients with ODM (54.3 ± 10.1 years) enrolled. Visfatin, RBP4, and MetS components were measured. The relationships between visfatin, RBP4 and MetS components were assessed in YDM and ODM. Results: The visfatin, but not the RPB4 level, was significantly higher in YDM than in ODM. After adjusting for age and body mass index, visfatin was not related to any MetS components except that there was a negative correlation with fasting plasma glucose (FPG). As for RPB4, triglyceride was found to be positively and FPG negatively related to RBP4 in YDM. However, in ODM, the only positive relationship that existed was between RBP4 and diastolic blood pressure. Conclusions: In conclusion, both visfatin and RBP4 had certain roles in diabetes and MetS although their relationships were different in YDM and ODM. Further studies are needed to explore their physiological and pathological effects in glucose metabolism. |
format | Online Article Text |
id | pubmed-10386173 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103861732023-07-30 Visfatin and Retinol Binding Protein-4 in Young-Onset Type 2 Diabetes Mellitus Huang, Ya-Li Chen, Yen-Lin Lin, Jiunn-Diann Pei, Dee Pitrone, Pietro Chen, Jin-Shuen Wu, Chung-Ze Medicina (Kaunas) Article Background and Objectives: The prevalence of type 2 diabetes mellitus in adolescents has increased rapidly in recent decades. However, the role of adipokines on pathophysiology in young-onset type 2 diabetes mellitus (YDM) is not clear. In this article, we explored the relationships between the adipokines (visfatin and retinol binding protein 4 (RBP4)) and metabolic syndrome (MetS) components in both YDM and late-onset type 2 diabetes mellitus (ODM). Materials and Methods: There were 36 patients with YDM (23.6 ± 4.8 years) and 36 patients with ODM (54.3 ± 10.1 years) enrolled. Visfatin, RBP4, and MetS components were measured. The relationships between visfatin, RBP4 and MetS components were assessed in YDM and ODM. Results: The visfatin, but not the RPB4 level, was significantly higher in YDM than in ODM. After adjusting for age and body mass index, visfatin was not related to any MetS components except that there was a negative correlation with fasting plasma glucose (FPG). As for RPB4, triglyceride was found to be positively and FPG negatively related to RBP4 in YDM. However, in ODM, the only positive relationship that existed was between RBP4 and diastolic blood pressure. Conclusions: In conclusion, both visfatin and RBP4 had certain roles in diabetes and MetS although their relationships were different in YDM and ODM. Further studies are needed to explore their physiological and pathological effects in glucose metabolism. MDPI 2023-07-09 /pmc/articles/PMC10386173/ /pubmed/37512089 http://dx.doi.org/10.3390/medicina59071278 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Huang, Ya-Li Chen, Yen-Lin Lin, Jiunn-Diann Pei, Dee Pitrone, Pietro Chen, Jin-Shuen Wu, Chung-Ze Visfatin and Retinol Binding Protein-4 in Young-Onset Type 2 Diabetes Mellitus |
title | Visfatin and Retinol Binding Protein-4 in Young-Onset Type 2 Diabetes Mellitus |
title_full | Visfatin and Retinol Binding Protein-4 in Young-Onset Type 2 Diabetes Mellitus |
title_fullStr | Visfatin and Retinol Binding Protein-4 in Young-Onset Type 2 Diabetes Mellitus |
title_full_unstemmed | Visfatin and Retinol Binding Protein-4 in Young-Onset Type 2 Diabetes Mellitus |
title_short | Visfatin and Retinol Binding Protein-4 in Young-Onset Type 2 Diabetes Mellitus |
title_sort | visfatin and retinol binding protein-4 in young-onset type 2 diabetes mellitus |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10386173/ https://www.ncbi.nlm.nih.gov/pubmed/37512089 http://dx.doi.org/10.3390/medicina59071278 |
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