A First-Class Degrader Candidate Targeting Both KRAS G12D and G12V Mediated by CANDDY Technology Independent of Ubiquitination

“Undruggable” targets such as KRAS are particularly challenging in the development of drugs. We devised a novel chemical knockdown strategy, CANDDY (Chemical knockdown with Affinity aNd Degradation DYnamics) technology, which promotes protein degradation using small molecules (CANDDY molecules) that...

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Detalles Bibliográficos
Autores principales: Miyamoto-Sato, Etsuko, Imanishi, Satoshi, Huang, Lijuan, Itakura, Shoko, Iwasaki, Yoichi, Ishizaka, Masamichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10386196/
https://www.ncbi.nlm.nih.gov/pubmed/37513471
http://dx.doi.org/10.3390/molecules28145600

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10386196/
https://www.ncbi.nlm.nih.gov/pubmed/37513471
http://dx.doi.org/10.3390/molecules28145600

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