Cargando…
The EAT-Lancet diet, genetic susceptibility and risk of atrial fibrillation in a population-based cohort
BACKGROUND: The EAT-Lancet Commission proposed a global reference diet with both human health benefits and environmental sustainability in 2019. However, evidence regarding the association of such a diet with the risk of atrial fibrillation (AF) is lacking. In addition, whether the genetic risk of A...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10386230/ https://www.ncbi.nlm.nih.gov/pubmed/37507726 http://dx.doi.org/10.1186/s12916-023-02985-6 |
_version_ | 1785081611872632832 |
---|---|
author | Zhang, Shunming Stubbendorff, Anna Ericson, Ulrika Wändell, Per Niu, Kaijun Qi, Lu Borné, Yan Sonestedt, Emily |
author_facet | Zhang, Shunming Stubbendorff, Anna Ericson, Ulrika Wändell, Per Niu, Kaijun Qi, Lu Borné, Yan Sonestedt, Emily |
author_sort | Zhang, Shunming |
collection | PubMed |
description | BACKGROUND: The EAT-Lancet Commission proposed a global reference diet with both human health benefits and environmental sustainability in 2019. However, evidence regarding the association of such a diet with the risk of atrial fibrillation (AF) is lacking. In addition, whether the genetic risk of AF can modify the effect of diet on AF remains unclear. This study aimed to assess the association of the EAT-Lancet diet with the risk of incident AF and examine the interaction between the EAT-Lancet diet and genetic susceptibility of AF. METHODS: This prospective study included 24,713 Swedish adults who were free of AF, coronary events, and stroke at baseline. Dietary habits were estimated with a modified diet history method, and an EAT-Lancet diet index was constructed to measure the EAT-Lancet reference diet. A weighted genetic risk score was constructed using 134 variants associated with AF. Cox proportional hazards regression models were applied to estimate the hazard ratio (HR) and 95% confidence interval (CI). RESULTS: During a median follow-up of 22.9 years, 4617 (18.7%) participants were diagnosed with AF. The multivariable HR (95% CI) of AF for the highest versus the lowest group for the EAT-Lancet diet index was 0.84 (0.73, 0.98) (P for trend < 0.01). The HR (95% CI) of AF per one SD increment of the EAT-Lancet diet index for high genetic risk was 0.92 (0.87, 0.98) (P for interaction = 0.15). CONCLUSIONS: Greater adherence to the EAT-Lancet diet index was significantly associated with a lower risk of incident AF. Such association tended to be stronger in participants with higher genetic risk, though gene-diet interaction was not significant. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12916-023-02985-6. |
format | Online Article Text |
id | pubmed-10386230 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-103862302023-07-30 The EAT-Lancet diet, genetic susceptibility and risk of atrial fibrillation in a population-based cohort Zhang, Shunming Stubbendorff, Anna Ericson, Ulrika Wändell, Per Niu, Kaijun Qi, Lu Borné, Yan Sonestedt, Emily BMC Med Research Article BACKGROUND: The EAT-Lancet Commission proposed a global reference diet with both human health benefits and environmental sustainability in 2019. However, evidence regarding the association of such a diet with the risk of atrial fibrillation (AF) is lacking. In addition, whether the genetic risk of AF can modify the effect of diet on AF remains unclear. This study aimed to assess the association of the EAT-Lancet diet with the risk of incident AF and examine the interaction between the EAT-Lancet diet and genetic susceptibility of AF. METHODS: This prospective study included 24,713 Swedish adults who were free of AF, coronary events, and stroke at baseline. Dietary habits were estimated with a modified diet history method, and an EAT-Lancet diet index was constructed to measure the EAT-Lancet reference diet. A weighted genetic risk score was constructed using 134 variants associated with AF. Cox proportional hazards regression models were applied to estimate the hazard ratio (HR) and 95% confidence interval (CI). RESULTS: During a median follow-up of 22.9 years, 4617 (18.7%) participants were diagnosed with AF. The multivariable HR (95% CI) of AF for the highest versus the lowest group for the EAT-Lancet diet index was 0.84 (0.73, 0.98) (P for trend < 0.01). The HR (95% CI) of AF per one SD increment of the EAT-Lancet diet index for high genetic risk was 0.92 (0.87, 0.98) (P for interaction = 0.15). CONCLUSIONS: Greater adherence to the EAT-Lancet diet index was significantly associated with a lower risk of incident AF. Such association tended to be stronger in participants with higher genetic risk, though gene-diet interaction was not significant. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12916-023-02985-6. BioMed Central 2023-07-28 /pmc/articles/PMC10386230/ /pubmed/37507726 http://dx.doi.org/10.1186/s12916-023-02985-6 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Article Zhang, Shunming Stubbendorff, Anna Ericson, Ulrika Wändell, Per Niu, Kaijun Qi, Lu Borné, Yan Sonestedt, Emily The EAT-Lancet diet, genetic susceptibility and risk of atrial fibrillation in a population-based cohort |
title | The EAT-Lancet diet, genetic susceptibility and risk of atrial fibrillation in a population-based cohort |
title_full | The EAT-Lancet diet, genetic susceptibility and risk of atrial fibrillation in a population-based cohort |
title_fullStr | The EAT-Lancet diet, genetic susceptibility and risk of atrial fibrillation in a population-based cohort |
title_full_unstemmed | The EAT-Lancet diet, genetic susceptibility and risk of atrial fibrillation in a population-based cohort |
title_short | The EAT-Lancet diet, genetic susceptibility and risk of atrial fibrillation in a population-based cohort |
title_sort | eat-lancet diet, genetic susceptibility and risk of atrial fibrillation in a population-based cohort |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10386230/ https://www.ncbi.nlm.nih.gov/pubmed/37507726 http://dx.doi.org/10.1186/s12916-023-02985-6 |
work_keys_str_mv | AT zhangshunming theeatlancetdietgeneticsusceptibilityandriskofatrialfibrillationinapopulationbasedcohort AT stubbendorffanna theeatlancetdietgeneticsusceptibilityandriskofatrialfibrillationinapopulationbasedcohort AT ericsonulrika theeatlancetdietgeneticsusceptibilityandriskofatrialfibrillationinapopulationbasedcohort AT wandellper theeatlancetdietgeneticsusceptibilityandriskofatrialfibrillationinapopulationbasedcohort AT niukaijun theeatlancetdietgeneticsusceptibilityandriskofatrialfibrillationinapopulationbasedcohort AT qilu theeatlancetdietgeneticsusceptibilityandriskofatrialfibrillationinapopulationbasedcohort AT borneyan theeatlancetdietgeneticsusceptibilityandriskofatrialfibrillationinapopulationbasedcohort AT sonestedtemily theeatlancetdietgeneticsusceptibilityandriskofatrialfibrillationinapopulationbasedcohort AT zhangshunming eatlancetdietgeneticsusceptibilityandriskofatrialfibrillationinapopulationbasedcohort AT stubbendorffanna eatlancetdietgeneticsusceptibilityandriskofatrialfibrillationinapopulationbasedcohort AT ericsonulrika eatlancetdietgeneticsusceptibilityandriskofatrialfibrillationinapopulationbasedcohort AT wandellper eatlancetdietgeneticsusceptibilityandriskofatrialfibrillationinapopulationbasedcohort AT niukaijun eatlancetdietgeneticsusceptibilityandriskofatrialfibrillationinapopulationbasedcohort AT qilu eatlancetdietgeneticsusceptibilityandriskofatrialfibrillationinapopulationbasedcohort AT borneyan eatlancetdietgeneticsusceptibilityandriskofatrialfibrillationinapopulationbasedcohort AT sonestedtemily eatlancetdietgeneticsusceptibilityandriskofatrialfibrillationinapopulationbasedcohort |