Advanced In Vivo Prediction by Introducing Biphasic Dissolution Data into PBPK Models

Coupling biorelevant in vitro dissolution with in silico physiological-based pharmacokinetic (PBPK) tools represents a promising method to describe and predict the in vivo performance of drug candidates in formulation development including non-passive transport, prodrug activation, and first-pass me...

Descripción completa

Detalles Bibliográficos
Autores principales: Denninger, Alexander, Becker, Tim, Westedt, Ulrich, Wagner, Karl G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10386266/
https://www.ncbi.nlm.nih.gov/pubmed/37514164
http://dx.doi.org/10.3390/pharmaceutics15071978

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10386266/
https://www.ncbi.nlm.nih.gov/pubmed/37514164
http://dx.doi.org/10.3390/pharmaceutics15071978

Ejemplares similares