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Advanced In Vivo Prediction by Introducing Biphasic Dissolution Data into PBPK Models

Coupling biorelevant in vitro dissolution with in silico physiological-based pharmacokinetic (PBPK) tools represents a promising method to describe and predict the in vivo performance of drug candidates in formulation development including non-passive transport, prodrug activation, and first-pass me...

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Detalles Bibliográficos
Autores principales:	Denninger, Alexander, Becker, Tim, Westedt, Ulrich, Wagner, Karl G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10386266/ https://www.ncbi.nlm.nih.gov/pubmed/37514164 http://dx.doi.org/10.3390/pharmaceutics15071978

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