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Contact Tracing and Tuberculosis Preventive Therapy for Household Child Contacts of Pulmonary Tuberculosis Patients in the Kyrgyz Republic: How Well Are We Doing?

Early identification, screening and investigation for tuberculosis (TB), and provision of TB preventive therapy (TPT), reduces risk of TB among child household contacts of pulmonary TB patients (index patients). A cohort study was conducted to describe the care cascade and timeliness of contact trac...

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Autores principales: Kadyrov, Meder, Thekkur, Pruthu, Geliukh, Evgenia, Sargsyan, Aelita, Goncharova, Olga, Kulzhabaeva, Aizat, Kadyrov, Asel, Khogali, Mohammed, Harries, Anthony D., Kadyrov, Abdullaat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10386269/
https://www.ncbi.nlm.nih.gov/pubmed/37505628
http://dx.doi.org/10.3390/tropicalmed8070332
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author Kadyrov, Meder
Thekkur, Pruthu
Geliukh, Evgenia
Sargsyan, Aelita
Goncharova, Olga
Kulzhabaeva, Aizat
Kadyrov, Asel
Khogali, Mohammed
Harries, Anthony D.
Kadyrov, Abdullaat
author_facet Kadyrov, Meder
Thekkur, Pruthu
Geliukh, Evgenia
Sargsyan, Aelita
Goncharova, Olga
Kulzhabaeva, Aizat
Kadyrov, Asel
Khogali, Mohammed
Harries, Anthony D.
Kadyrov, Abdullaat
author_sort Kadyrov, Meder
collection PubMed
description Early identification, screening and investigation for tuberculosis (TB), and provision of TB preventive therapy (TPT), reduces risk of TB among child household contacts of pulmonary TB patients (index patients). A cohort study was conducted to describe the care cascade and timeliness of contact tracing and TPT initiation among child household contacts (aged < 15 years) of index patients initiated on TB treatment in Bishkek, the Kyrgyz Republic during October 2021–September 2022. In the register, information on the number of child household contacts was available for 153 (18%) of 873 index patients. Of 297 child household contacts identified, data were available for 285, of whom 261 (92%) were screened for TB. More than 50% were screened after 1 month of the index patient initiating TB treatment. TB was diagnosed in 23/285 (9%, 95% CI: 6–13%) children. Of 238 TB-free children, 130 (55%) were eligible for TPT. Of the latter, 64 (49%) were initiated on TPT, of whom 52 (81%) completed TPT. While TPT completion was excellent, there was deficiency in contact identification, timely screening and TPT initiation. Thus, healthcare providers should diligently request and record details of child household contacts, adhere to contact tracing timelines and counsel caregivers regarding TPT.
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spelling pubmed-103862692023-07-30 Contact Tracing and Tuberculosis Preventive Therapy for Household Child Contacts of Pulmonary Tuberculosis Patients in the Kyrgyz Republic: How Well Are We Doing? Kadyrov, Meder Thekkur, Pruthu Geliukh, Evgenia Sargsyan, Aelita Goncharova, Olga Kulzhabaeva, Aizat Kadyrov, Asel Khogali, Mohammed Harries, Anthony D. Kadyrov, Abdullaat Trop Med Infect Dis Article Early identification, screening and investigation for tuberculosis (TB), and provision of TB preventive therapy (TPT), reduces risk of TB among child household contacts of pulmonary TB patients (index patients). A cohort study was conducted to describe the care cascade and timeliness of contact tracing and TPT initiation among child household contacts (aged < 15 years) of index patients initiated on TB treatment in Bishkek, the Kyrgyz Republic during October 2021–September 2022. In the register, information on the number of child household contacts was available for 153 (18%) of 873 index patients. Of 297 child household contacts identified, data were available for 285, of whom 261 (92%) were screened for TB. More than 50% were screened after 1 month of the index patient initiating TB treatment. TB was diagnosed in 23/285 (9%, 95% CI: 6–13%) children. Of 238 TB-free children, 130 (55%) were eligible for TPT. Of the latter, 64 (49%) were initiated on TPT, of whom 52 (81%) completed TPT. While TPT completion was excellent, there was deficiency in contact identification, timely screening and TPT initiation. Thus, healthcare providers should diligently request and record details of child household contacts, adhere to contact tracing timelines and counsel caregivers regarding TPT. MDPI 2023-06-21 /pmc/articles/PMC10386269/ /pubmed/37505628 http://dx.doi.org/10.3390/tropicalmed8070332 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kadyrov, Meder
Thekkur, Pruthu
Geliukh, Evgenia
Sargsyan, Aelita
Goncharova, Olga
Kulzhabaeva, Aizat
Kadyrov, Asel
Khogali, Mohammed
Harries, Anthony D.
Kadyrov, Abdullaat
Contact Tracing and Tuberculosis Preventive Therapy for Household Child Contacts of Pulmonary Tuberculosis Patients in the Kyrgyz Republic: How Well Are We Doing?
title Contact Tracing and Tuberculosis Preventive Therapy for Household Child Contacts of Pulmonary Tuberculosis Patients in the Kyrgyz Republic: How Well Are We Doing?
title_full Contact Tracing and Tuberculosis Preventive Therapy for Household Child Contacts of Pulmonary Tuberculosis Patients in the Kyrgyz Republic: How Well Are We Doing?
title_fullStr Contact Tracing and Tuberculosis Preventive Therapy for Household Child Contacts of Pulmonary Tuberculosis Patients in the Kyrgyz Republic: How Well Are We Doing?
title_full_unstemmed Contact Tracing and Tuberculosis Preventive Therapy for Household Child Contacts of Pulmonary Tuberculosis Patients in the Kyrgyz Republic: How Well Are We Doing?
title_short Contact Tracing and Tuberculosis Preventive Therapy for Household Child Contacts of Pulmonary Tuberculosis Patients in the Kyrgyz Republic: How Well Are We Doing?
title_sort contact tracing and tuberculosis preventive therapy for household child contacts of pulmonary tuberculosis patients in the kyrgyz republic: how well are we doing?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10386269/
https://www.ncbi.nlm.nih.gov/pubmed/37505628
http://dx.doi.org/10.3390/tropicalmed8070332
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