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Application of Baculovirus Expression Vector System (BEVS) in Vaccine Development

Vaccination is one of the most effective strategies to control epidemics. With the deepening of people’s awareness of vaccination, there is a high demand for vaccination. Hence, a flexible, rapid, and cost-effective vaccine platform is urgently needed. The baculovirus expression vector system (BEVS)...

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Detalles Bibliográficos
Autores principales: Hong, Qiaonan, Liu, Jian, Wei, Yuquan, Wei, Xiawei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10386281/
https://www.ncbi.nlm.nih.gov/pubmed/37515034
http://dx.doi.org/10.3390/vaccines11071218
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author Hong, Qiaonan
Liu, Jian
Wei, Yuquan
Wei, Xiawei
author_facet Hong, Qiaonan
Liu, Jian
Wei, Yuquan
Wei, Xiawei
author_sort Hong, Qiaonan
collection PubMed
description Vaccination is one of the most effective strategies to control epidemics. With the deepening of people’s awareness of vaccination, there is a high demand for vaccination. Hence, a flexible, rapid, and cost-effective vaccine platform is urgently needed. The baculovirus expression vector system (BEVS) has emerged as a promising technology for vaccine production due to its high safety, rapid production, flexible product design, and scalability. In this review, we introduced the development history of BEVS and the procedures for preparing recombinant protein vaccines using the BEVS platform and summarized the features and limitations of this platform. Furthermore, we highlighted the progress of the BEVS platform-related research, especially in the field of vaccine. Finally, we provided a new prospect for BEVS in future vaccine manufacturing, which may pave the way for future BEVS-derived vaccine development.
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spelling pubmed-103862812023-07-30 Application of Baculovirus Expression Vector System (BEVS) in Vaccine Development Hong, Qiaonan Liu, Jian Wei, Yuquan Wei, Xiawei Vaccines (Basel) Review Vaccination is one of the most effective strategies to control epidemics. With the deepening of people’s awareness of vaccination, there is a high demand for vaccination. Hence, a flexible, rapid, and cost-effective vaccine platform is urgently needed. The baculovirus expression vector system (BEVS) has emerged as a promising technology for vaccine production due to its high safety, rapid production, flexible product design, and scalability. In this review, we introduced the development history of BEVS and the procedures for preparing recombinant protein vaccines using the BEVS platform and summarized the features and limitations of this platform. Furthermore, we highlighted the progress of the BEVS platform-related research, especially in the field of vaccine. Finally, we provided a new prospect for BEVS in future vaccine manufacturing, which may pave the way for future BEVS-derived vaccine development. MDPI 2023-07-08 /pmc/articles/PMC10386281/ /pubmed/37515034 http://dx.doi.org/10.3390/vaccines11071218 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Hong, Qiaonan
Liu, Jian
Wei, Yuquan
Wei, Xiawei
Application of Baculovirus Expression Vector System (BEVS) in Vaccine Development
title Application of Baculovirus Expression Vector System (BEVS) in Vaccine Development
title_full Application of Baculovirus Expression Vector System (BEVS) in Vaccine Development
title_fullStr Application of Baculovirus Expression Vector System (BEVS) in Vaccine Development
title_full_unstemmed Application of Baculovirus Expression Vector System (BEVS) in Vaccine Development
title_short Application of Baculovirus Expression Vector System (BEVS) in Vaccine Development
title_sort application of baculovirus expression vector system (bevs) in vaccine development
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10386281/
https://www.ncbi.nlm.nih.gov/pubmed/37515034
http://dx.doi.org/10.3390/vaccines11071218
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