hESC-derived striatal progenitors grafted into a Huntington’s disease rat model support long-term functional motor recovery by differentiating, self-organizing and connecting into the lesioned striatum

BACKGROUND: Huntington’s disease (HD) is a motor and cognitive neurodegenerative disorder due to prominent loss of striatal medium spiny neurons (MSNs). Cell replacement using human embryonic stem cells (hESCs) derivatives may offer new therapeutic opportunities to replace degenerated neurons and re...

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Detalles Bibliográficos
Autores principales: Schellino, Roberta, Besusso, Dario, Parolisi, Roberta, Gómez-González, Gabriela B., Dallere, Sveva, Scaramuzza, Linda, Ribodino, Marta, Campus, Ilaria, Conforti, Paola, Parmar, Malin, Boido, Marina, Cattaneo, Elena, Buffo, Annalisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10386300/
https://www.ncbi.nlm.nih.gov/pubmed/37507794
http://dx.doi.org/10.1186/s13287-023-03422-4

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