Cargando…

Drug-Repurposing Strategy for Dimethyl Fumarate

In the area of drug discovery, repurposing strategies represent an approach to discover new uses of approved drugs besides their original indications. We used this approach to investigate the effects of dimethyl fumarate (DMF), a drug approved for relapsing–remitting multiple sclerosis and psoriasis...

Descripción completa

Detalles Bibliográficos
Autores principales:	Giunta, Salvatore, D’Amico, Agata Grazia, Maugeri, Grazia, Bucolo, Claudio, Romano, Giovanni Luca, Rossi, Settimio, Eandi, Chiara M., Pricoco, Elisabetta, D’Agata, Velia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10386358/ https://www.ncbi.nlm.nih.gov/pubmed/37513886 http://dx.doi.org/10.3390/ph16070974

Ejemplares similares

Attenuation of High Glucose-Induced Damage in RPE Cells through p38 MAPK Signaling Pathway Inhibition
por: Maugeri, Grazia, et al.
Publicado: (2021)

Corneal wound healing and nerve regeneration by novel ophthalmic formulations based on cross-linked sodium hyaluronate, taurine, vitamin B6, and vitamin B12
por: Bucolo, Claudio, et al.
Publicado: (2023)

Editorial: Uveal melanoma: from lab bench to clinic – new therapeutic advances
por: D'Amico, Agata Grazia, et al.
Publicado: (2023)

Activity-Dependent Neuroprotective Protein (ADNP)-Derived Peptide (NAP) Counteracts UV-B Radiation-Induced ROS Formation in Corneal Epithelium
por: Maugeri, Grazia, et al.
Publicado: (2022)

Effects of PACAP on Schwann Cells: Focus on Nerve Injury
por: Maugeri, Grazia, et al.
Publicado: (2020)

Activity-Dependent Neuroprotective Protein (ADNP): An Overview of Its Role in the Eye
por: Maugeri, Grazia, et al.
Publicado: (2022)

PACAP and VIP Inhibit the Invasiveness of Glioblastoma Cells Exposed to Hypoxia through the Regulation of HIFs and EGFR Expression
por: Maugeri, Grazia, et al.
Publicado: (2016)

PACAP Modulates the Autophagy Process in an In Vitro Model of Amyotrophic Lateral Sclerosis
por: D’Amico, Agata Grazia, et al.
Publicado: (2020)

Differential Vulnerability of Oculomotor Versus Hypoglossal Nucleus During ALS: Involvement of PACAP
por: Maugeri, Grazia, et al.
Publicado: (2020)

Multimodal Role of PACAP in Glioblastoma
por: D’Amico, Agata Grazia, et al.
Publicado: (2021)

Effect of PACAP on Hypoxia-Induced Angiogenesis and Epithelial–Mesenchymal Transition in Glioblastoma
por: Maugeri, Grazia, et al.
Publicado: (2021)

Cell Cycle Reactivation, at the Start of Neurodegeneration, Induced by Forskolin and Aniline in Differentiated Neuroblastoma Cells
por: Sturiale, Valentina, et al.
Publicado: (2023)

Regulation of UV-B-Induced Inflammatory Mediators by Activity-Dependent Neuroprotective Protein (ADNP)-Derived Peptide (NAP) in Corneal Epithelium
por: Maugeri, Grazia, et al.
Publicado: (2023)

Effects of Physical Activity on Amyotrophic Lateral Sclerosis
por: Maugeri, Grazia, et al.
Publicado: (2020)

Expression profile of Wilms Tumor 1 (WT1) isoforms in undifferentiated and all-trans retinoic acid differentiated neuroblastoma cells
por: Maugeri, Grazia, et al.
Publicado: (2016)

Exploiting real-world data to monitor physical activity in patients with osteoarthritis: the opportunity of digital epidemiology()
por: Ravalli, Silvia, et al.
Publicado: (2022)

Role of exercise in the brain: focus on oligodendrocytes and remyelination
por: Maugeri, Grazia, et al.
Publicado: (2023)

CXCR2 Is Deregulated in ALS Spinal Cord and Its Activation Triggers Apoptosis in Motor Neuron-Like Cells Overexpressing hSOD1-G93A
por: La Cognata, Valentina, et al.
Publicado: (2023)

Beneficial Effects of Physical Activity on Subjects with Neurodegenerative Disease
por: Vizzi, Laura, et al.
Publicado: (2020)

The ε-Isozyme of Protein Kinase C (PKCε) Is Impaired in ALS Motor Cortex and Its Pulse Activation by Bryostatin-1 Produces Long Term Survival in Degenerating SOD1-G93A Motor Neuron-like Cells
por: La Cognata, Valentina, et al.
Publicado: (2023)

The Practice of Physical Activity on Psychological, Mental, Physical, and Social Wellbeing for Breast-Cancer Survivors: An Umbrella Review
por: Zanghì, Marta, et al.
Publicado: (2022)

Methodological consideration for a physical activity intervention in breast cancer population: An umbrella review
por: Petrigna, Luca, et al.
Publicado: (2023)

Evaluation of the Antioxidant and Antiangiogenic Activity of a Pomegranate Extract in BPH-1 Prostate Epithelial Cells
por: Consoli, Valeria, et al.
Publicado: (2023)

Effects of Exercise on Skeletal Muscle Pathophysiology in Huntington’s Disease
por: Trovato, Bruno, et al.
Publicado: (2022)

Fingolimod and Diabetic Retinopathy: A Drug Repurposing Study
por: Gesualdo, Carlo, et al.
Publicado: (2021)

The “Journal of Functional Morphology and Kinesiology” Journal Club Series: Highlights on Recent Papers in Overtraining and Exercise Addiction
por: Bianco, Antonino, et al.
Publicado: (2019)

The Challenge of Dimethyl Fumarate Repurposing in Eye Pathologies
por: Manai, Federico, et al.
Publicado: (2022)

Protective Effects of PACAP in Peripheral Organs
por: Toth, Denes, et al.
Publicado: (2020)

An Overview of Physical Exercise Program Protocols and Effects on the Physical Function in Multiple Sclerosis: An Umbrella Review
por: Sortino, Martina, et al.
Publicado: (2023)

Assessment of a New Nanostructured Microemulsion System for Ocular Delivery of Sorafenib to Posterior Segment of the Eye
por: Santonocito, Manuela, et al.
Publicado: (2021)

The impact of physical activity on psychological health during Covid-19 pandemic in Italy
por: Maugeri, Grazia, et al.
Publicado: (2020)

The role of exercise on peripheral nerve regeneration: from animal model to clinical application
por: Maugeri, Grazia, et al.
Publicado: (2021)

Neuroprotective Effects of Physical Activity via the Adaptation of Astrocytes
por: Maugeri, Grazia, et al.
Publicado: (2021)

Combination of Heme Oxygenase-1 Inhibition and Sigma Receptor Modulation for Anticancer Activity
por: Romeo, Giuseppe, et al.
Publicado: (2021)

Novel Heme Oxygenase-1 (HO-1) Inducers Based on Dimethyl Fumarate Structure
por: Sorrenti, Valeria, et al.
Publicado: (2020)

Joint Mobility Protection during the Developmental Age among Free Climbing Practitioners: A Pilot Study
por: Gasbarro, Ludovica, et al.
Publicado: (2020)

The Influence of Exercise on Oxidative Stress after Spinal Cord Injury: A Narrative Review
por: Maugeri, Grazia, et al.
Publicado: (2023)

Repurposing dimethyl fumarate as an antiepileptogenic and disease-modifying treatment for drug-resistant epilepsy
por: Sandouka, Sereen, et al.
Publicado: (2023)

Repurposing Dimethyl Fumarate for Cardiovascular Diseases: Pharmacological Effects, Molecular Mechanisms, and Therapeutic Promise
por: Thomas, Shilu Deepa, et al.
Publicado: (2022)

Glucose-Impaired Corneal Re-Epithelialization Is Promoted by a Novel Derivate of Dimethyl Fumarate
por: Giurdanella, Giovanni, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_7pn3roa0ndgqg2l4c4mnu8qg3k