Alkali metal cations modulate the geometry of different binding sites in HCN4 selectivity filter for permeation or block

Hyperpolarization-activated cyclic-nucleotide gated (HCN) channels are important for timing biological processes like heartbeat and neuronal firing. Their weak cation selectivity is determined by a filter domain with only two binding sites for K(+) and one for Na(+). The latter acts as a weak blocke...

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Detalles Bibliográficos
Autores principales: Krumbach, Jan H., Bauer, Daniel, Sharifzadeh, Atiyeh Sadat, Saponaro, Andrea, Lautenschläger, Rene, Lange, Kristina, Rauh, Oliver, DiFrancesco, Dario, Moroni, Anna, Thiel, Gerhard, Hamacher, Kay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10386491/
https://www.ncbi.nlm.nih.gov/pubmed/37523352
http://dx.doi.org/10.1085/jgp.202313364

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