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Pharmacological Activities of Schiff Bases and Their Derivatives with Low and High Molecular Phosphonates

This review paper is focused on the design of anthracene and furan-containing Schiff bases and their advanced properties as ligands in complex transition metal ions The paper also provides a brief overview on a variety of biological applications, namely, potent candidates with antibacterial and anti...

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Autores principales: Tsacheva, Ivelina, Todorova, Zornica, Momekova, Denitsa, Momekov, Georgi, Koseva, Neli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10386503/
https://www.ncbi.nlm.nih.gov/pubmed/37513849
http://dx.doi.org/10.3390/ph16070938
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author Tsacheva, Ivelina
Todorova, Zornica
Momekova, Denitsa
Momekov, Georgi
Koseva, Neli
author_facet Tsacheva, Ivelina
Todorova, Zornica
Momekova, Denitsa
Momekov, Georgi
Koseva, Neli
author_sort Tsacheva, Ivelina
collection PubMed
description This review paper is focused on the design of anthracene and furan-containing Schiff bases and their advanced properties as ligands in complex transition metal ions The paper also provides a brief overview on a variety of biological applications, namely, potent candidates with antibacterial and antifungal activity, antioxidant and chemosensing properties. These advantageous properties are enhanced upon metal complexing. The subject of the review has been extended with a brief discussion on reactivity of Schiff bases with hydrogen phosphonates and the preparation of low and high molecular phosphonates, as well as their application as pharmacological agents. This work will be of interest for scientists seeking new challenges in discovering advanced pharmacological active molecules gaining inspiration from the versatile families of imines and aminophosphonates.
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spelling pubmed-103865032023-07-30 Pharmacological Activities of Schiff Bases and Their Derivatives with Low and High Molecular Phosphonates Tsacheva, Ivelina Todorova, Zornica Momekova, Denitsa Momekov, Georgi Koseva, Neli Pharmaceuticals (Basel) Review This review paper is focused on the design of anthracene and furan-containing Schiff bases and their advanced properties as ligands in complex transition metal ions The paper also provides a brief overview on a variety of biological applications, namely, potent candidates with antibacterial and antifungal activity, antioxidant and chemosensing properties. These advantageous properties are enhanced upon metal complexing. The subject of the review has been extended with a brief discussion on reactivity of Schiff bases with hydrogen phosphonates and the preparation of low and high molecular phosphonates, as well as their application as pharmacological agents. This work will be of interest for scientists seeking new challenges in discovering advanced pharmacological active molecules gaining inspiration from the versatile families of imines and aminophosphonates. MDPI 2023-06-28 /pmc/articles/PMC10386503/ /pubmed/37513849 http://dx.doi.org/10.3390/ph16070938 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tsacheva, Ivelina
Todorova, Zornica
Momekova, Denitsa
Momekov, Georgi
Koseva, Neli
Pharmacological Activities of Schiff Bases and Their Derivatives with Low and High Molecular Phosphonates
title Pharmacological Activities of Schiff Bases and Their Derivatives with Low and High Molecular Phosphonates
title_full Pharmacological Activities of Schiff Bases and Their Derivatives with Low and High Molecular Phosphonates
title_fullStr Pharmacological Activities of Schiff Bases and Their Derivatives with Low and High Molecular Phosphonates
title_full_unstemmed Pharmacological Activities of Schiff Bases and Their Derivatives with Low and High Molecular Phosphonates
title_short Pharmacological Activities of Schiff Bases and Their Derivatives with Low and High Molecular Phosphonates
title_sort pharmacological activities of schiff bases and their derivatives with low and high molecular phosphonates
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10386503/
https://www.ncbi.nlm.nih.gov/pubmed/37513849
http://dx.doi.org/10.3390/ph16070938
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