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Cyclodextrin’s Effect on Permeability and Partition of Nortriptyline Hydrochloride

Cyclodextrin-based delivery systems have been intensively used to improve the bioavailability of drugs through the modification of their pharmaceutically relevant properties, such as solubility, distribution and membrane permeation. The present work aimed to disclose the influence of HP-β-CD and SBE...

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Autores principales: Volkova, Tatyana, Simonova, Olga, Perlovich, German
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10386514/
https://www.ncbi.nlm.nih.gov/pubmed/37513934
http://dx.doi.org/10.3390/ph16071022
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author Volkova, Tatyana
Simonova, Olga
Perlovich, German
author_facet Volkova, Tatyana
Simonova, Olga
Perlovich, German
author_sort Volkova, Tatyana
collection PubMed
description Cyclodextrin-based delivery systems have been intensively used to improve the bioavailability of drugs through the modification of their pharmaceutically relevant properties, such as solubility, distribution and membrane permeation. The present work aimed to disclose the influence of HP-β-CD and SBE-β-CD on the distribution and permeability of nortriptyline hydrochloride (NTT•HCl), a tricyclic antidepressant drug. To this end, the distribution coefficients in the 1-octanol/buffer and n-hexane/buffer model systems and the coefficients of permeability through the cellulose membrane and lipophilic PermeaPad barrier were determined at several cyclodextrin concentrations. The results demonstrated a dramatic decrease in both the distribution and the permeability coefficients as the cyclodextrin concentration rose, with the decrease being more pronounced in SBE-β-CD due to the charge–charge attraction and electrostatic interactions between NTT and SBE-β-CD. It is these interactions that were shown to be responsible for the greater value of the constant of NTT’s association with SBE-β-CD than that with HP-β-CD. The findings of this study revealed similar trends in the 1-octanol/buffer 6.8 pH distribution and permeability through the PermeaPad barrier in the presence of CDs. These results were attributed to the determinative role of the distribution coefficient (serving as a descriptor) in permeation through the PermeaPad barrier modeling the lipophilic nature of biological barriers.
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spelling pubmed-103865142023-07-30 Cyclodextrin’s Effect on Permeability and Partition of Nortriptyline Hydrochloride Volkova, Tatyana Simonova, Olga Perlovich, German Pharmaceuticals (Basel) Article Cyclodextrin-based delivery systems have been intensively used to improve the bioavailability of drugs through the modification of their pharmaceutically relevant properties, such as solubility, distribution and membrane permeation. The present work aimed to disclose the influence of HP-β-CD and SBE-β-CD on the distribution and permeability of nortriptyline hydrochloride (NTT•HCl), a tricyclic antidepressant drug. To this end, the distribution coefficients in the 1-octanol/buffer and n-hexane/buffer model systems and the coefficients of permeability through the cellulose membrane and lipophilic PermeaPad barrier were determined at several cyclodextrin concentrations. The results demonstrated a dramatic decrease in both the distribution and the permeability coefficients as the cyclodextrin concentration rose, with the decrease being more pronounced in SBE-β-CD due to the charge–charge attraction and electrostatic interactions between NTT and SBE-β-CD. It is these interactions that were shown to be responsible for the greater value of the constant of NTT’s association with SBE-β-CD than that with HP-β-CD. The findings of this study revealed similar trends in the 1-octanol/buffer 6.8 pH distribution and permeability through the PermeaPad barrier in the presence of CDs. These results were attributed to the determinative role of the distribution coefficient (serving as a descriptor) in permeation through the PermeaPad barrier modeling the lipophilic nature of biological barriers. MDPI 2023-07-19 /pmc/articles/PMC10386514/ /pubmed/37513934 http://dx.doi.org/10.3390/ph16071022 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Volkova, Tatyana
Simonova, Olga
Perlovich, German
Cyclodextrin’s Effect on Permeability and Partition of Nortriptyline Hydrochloride
title Cyclodextrin’s Effect on Permeability and Partition of Nortriptyline Hydrochloride
title_full Cyclodextrin’s Effect on Permeability and Partition of Nortriptyline Hydrochloride
title_fullStr Cyclodextrin’s Effect on Permeability and Partition of Nortriptyline Hydrochloride
title_full_unstemmed Cyclodextrin’s Effect on Permeability and Partition of Nortriptyline Hydrochloride
title_short Cyclodextrin’s Effect on Permeability and Partition of Nortriptyline Hydrochloride
title_sort cyclodextrin’s effect on permeability and partition of nortriptyline hydrochloride
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10386514/
https://www.ncbi.nlm.nih.gov/pubmed/37513934
http://dx.doi.org/10.3390/ph16071022
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