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Unveiling the Impact of the Omicron Variant: Insights from Genomic Surveillance in Mato Grosso do Sul, Midwest Brazil
Genomic surveillance has emerged as a crucial tool in monitoring and understanding the dynamics of viral variants during the COVID-19 pandemic. In the Midwest region of Brazil, Mato Grosso do Sul has faced a significant burden from the SARS-CoV-2 epidemic, with a total of 613,000 confirmed cases as...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10386548/ https://www.ncbi.nlm.nih.gov/pubmed/37515290 http://dx.doi.org/10.3390/v15071604 |
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author | de Mello Almeida Maziero, Lívia Giovanetti, Marta Fonseca, Vagner Zardin, Marina Castilhos Souza Umaki de Castro Lichs, Gislene Garcia de Rezende Romera, Grazielli Rocha Tsuha, Daniel Henrique Frias, Danila Fernanda Rodrigues Escandolhero, Valdir Castanho Demarchi, Luiz Henrique Domingues Castilho, Larissa Barbosa, Karine Ferreira Tebet, Danielle Galindo Martins Xavier, Joilson Fritsch, Hegger Lima, Mauricio de Oliveira, Carla Santos, Elaine Vieira Kashima, Simone Said, Rodrigo Fabiano do Carmo Rosewell, Alexander Croda, Julio Alcantara, Luiz Carlos Junior Cavalheiro Maymone Gonçalves, Crhistinne |
author_facet | de Mello Almeida Maziero, Lívia Giovanetti, Marta Fonseca, Vagner Zardin, Marina Castilhos Souza Umaki de Castro Lichs, Gislene Garcia de Rezende Romera, Grazielli Rocha Tsuha, Daniel Henrique Frias, Danila Fernanda Rodrigues Escandolhero, Valdir Castanho Demarchi, Luiz Henrique Domingues Castilho, Larissa Barbosa, Karine Ferreira Tebet, Danielle Galindo Martins Xavier, Joilson Fritsch, Hegger Lima, Mauricio de Oliveira, Carla Santos, Elaine Vieira Kashima, Simone Said, Rodrigo Fabiano do Carmo Rosewell, Alexander Croda, Julio Alcantara, Luiz Carlos Junior Cavalheiro Maymone Gonçalves, Crhistinne |
author_sort | de Mello Almeida Maziero, Lívia |
collection | PubMed |
description | Genomic surveillance has emerged as a crucial tool in monitoring and understanding the dynamics of viral variants during the COVID-19 pandemic. In the Midwest region of Brazil, Mato Grosso do Sul has faced a significant burden from the SARS-CoV-2 epidemic, with a total of 613,000 confirmed cases as of June 2023. In collaboration with the Central Public Health Laboratory in the capital city of Campo Grande, we conducted a portable whole-genome sequencing and phylodynamic analysis to investigate the circulation of the Omicron variant in the region. The study aimed to uncover the genomic landscape and provide valuable insights into the prevalence and transmission patterns of this highly transmissible variant. Our findings revealed an increase in the number of cases within the region during 2022, followed by a gradual decline as a result of the successful impact of the vaccination program together with the capacity of this unpredictable and very transmissible variant to quickly affect the proportion of susceptible population. Genomic data indicated multiple introduction events, suggesting that human mobility played a differential role in the variant’s dispersion dynamics throughout the state. These findings emphasize the significance of implementing public health interventions to mitigate further spread and highlight the powerful role of genomic monitoring in promptly tracking and uncovering the circulation of viral strains. Together those results underscore the importance of proactive surveillance, rapid genomic sequencing, and data sharing to facilitate timely public health responses. |
format | Online Article Text |
id | pubmed-10386548 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103865482023-07-30 Unveiling the Impact of the Omicron Variant: Insights from Genomic Surveillance in Mato Grosso do Sul, Midwest Brazil de Mello Almeida Maziero, Lívia Giovanetti, Marta Fonseca, Vagner Zardin, Marina Castilhos Souza Umaki de Castro Lichs, Gislene Garcia de Rezende Romera, Grazielli Rocha Tsuha, Daniel Henrique Frias, Danila Fernanda Rodrigues Escandolhero, Valdir Castanho Demarchi, Luiz Henrique Domingues Castilho, Larissa Barbosa, Karine Ferreira Tebet, Danielle Galindo Martins Xavier, Joilson Fritsch, Hegger Lima, Mauricio de Oliveira, Carla Santos, Elaine Vieira Kashima, Simone Said, Rodrigo Fabiano do Carmo Rosewell, Alexander Croda, Julio Alcantara, Luiz Carlos Junior Cavalheiro Maymone Gonçalves, Crhistinne Viruses Brief Report Genomic surveillance has emerged as a crucial tool in monitoring and understanding the dynamics of viral variants during the COVID-19 pandemic. In the Midwest region of Brazil, Mato Grosso do Sul has faced a significant burden from the SARS-CoV-2 epidemic, with a total of 613,000 confirmed cases as of June 2023. In collaboration with the Central Public Health Laboratory in the capital city of Campo Grande, we conducted a portable whole-genome sequencing and phylodynamic analysis to investigate the circulation of the Omicron variant in the region. The study aimed to uncover the genomic landscape and provide valuable insights into the prevalence and transmission patterns of this highly transmissible variant. Our findings revealed an increase in the number of cases within the region during 2022, followed by a gradual decline as a result of the successful impact of the vaccination program together with the capacity of this unpredictable and very transmissible variant to quickly affect the proportion of susceptible population. Genomic data indicated multiple introduction events, suggesting that human mobility played a differential role in the variant’s dispersion dynamics throughout the state. These findings emphasize the significance of implementing public health interventions to mitigate further spread and highlight the powerful role of genomic monitoring in promptly tracking and uncovering the circulation of viral strains. Together those results underscore the importance of proactive surveillance, rapid genomic sequencing, and data sharing to facilitate timely public health responses. MDPI 2023-07-22 /pmc/articles/PMC10386548/ /pubmed/37515290 http://dx.doi.org/10.3390/v15071604 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Brief Report de Mello Almeida Maziero, Lívia Giovanetti, Marta Fonseca, Vagner Zardin, Marina Castilhos Souza Umaki de Castro Lichs, Gislene Garcia de Rezende Romera, Grazielli Rocha Tsuha, Daniel Henrique Frias, Danila Fernanda Rodrigues Escandolhero, Valdir Castanho Demarchi, Luiz Henrique Domingues Castilho, Larissa Barbosa, Karine Ferreira Tebet, Danielle Galindo Martins Xavier, Joilson Fritsch, Hegger Lima, Mauricio de Oliveira, Carla Santos, Elaine Vieira Kashima, Simone Said, Rodrigo Fabiano do Carmo Rosewell, Alexander Croda, Julio Alcantara, Luiz Carlos Junior Cavalheiro Maymone Gonçalves, Crhistinne Unveiling the Impact of the Omicron Variant: Insights from Genomic Surveillance in Mato Grosso do Sul, Midwest Brazil |
title | Unveiling the Impact of the Omicron Variant: Insights from Genomic Surveillance in Mato Grosso do Sul, Midwest Brazil |
title_full | Unveiling the Impact of the Omicron Variant: Insights from Genomic Surveillance in Mato Grosso do Sul, Midwest Brazil |
title_fullStr | Unveiling the Impact of the Omicron Variant: Insights from Genomic Surveillance in Mato Grosso do Sul, Midwest Brazil |
title_full_unstemmed | Unveiling the Impact of the Omicron Variant: Insights from Genomic Surveillance in Mato Grosso do Sul, Midwest Brazil |
title_short | Unveiling the Impact of the Omicron Variant: Insights from Genomic Surveillance in Mato Grosso do Sul, Midwest Brazil |
title_sort | unveiling the impact of the omicron variant: insights from genomic surveillance in mato grosso do sul, midwest brazil |
topic | Brief Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10386548/ https://www.ncbi.nlm.nih.gov/pubmed/37515290 http://dx.doi.org/10.3390/v15071604 |
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