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Determinants of Pesticide Exposure in Occupational Studies: A Meta-Analysis

Few epidemiological studies use exposure determinants specifically tailored to assess pesticide or plant protection product (PPP) exposures when assessing presumed association between occupational exposure and health outcomes among agricultural workers. This lack of exposure specificity could lead t...

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Autores principales: Oltramare, Christelle, Mediouni, Zakia, Shoman, Yara, Hopf, Nancy B., Graczyk, Halshka, Berthet, Aurélie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10386710/
https://www.ncbi.nlm.nih.gov/pubmed/37505588
http://dx.doi.org/10.3390/toxics11070623
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author Oltramare, Christelle
Mediouni, Zakia
Shoman, Yara
Hopf, Nancy B.
Graczyk, Halshka
Berthet, Aurélie
author_facet Oltramare, Christelle
Mediouni, Zakia
Shoman, Yara
Hopf, Nancy B.
Graczyk, Halshka
Berthet, Aurélie
author_sort Oltramare, Christelle
collection PubMed
description Few epidemiological studies use exposure determinants specifically tailored to assess pesticide or plant protection product (PPP) exposures when assessing presumed association between occupational exposure and health outcomes among agricultural workers. This lack of exposure specificity could lead to results that fail to detect an association. It could be related to the lack of consensus on exposure assessment methods and the choice of exposure determinants. We conducted a meta-analysis following the PRISMA checklist to identify PPP exposure determinants used in occupational studies and identified exposure determinants that best characterized agricultural exposures to PPPs. Out of 1436 studies identified, 71 were included. The exposure determinants identified were active ingredients, chemical classes, types of PPP, crops, tasks, frequencies, duration, lifetime exposure days, and intensity-weighted exposure days. Only six over 17 associations between exposure determinants and health outcomes were found with moderate quality of evidence. Overall, epidemiological studies had difficulty defining relevant determinants to characterize PPP exposures for agricultural workers. We recommend that a standardized list of determinants for PPP exposures in occupational exposure studies should include information on formulations, intensity, duration, and frequency of PPP exposure. Harmonized data collection on exposure and health outcomes are required as well as standard units for each exposure determinant.
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spelling pubmed-103867102023-07-30 Determinants of Pesticide Exposure in Occupational Studies: A Meta-Analysis Oltramare, Christelle Mediouni, Zakia Shoman, Yara Hopf, Nancy B. Graczyk, Halshka Berthet, Aurélie Toxics Systematic Review Few epidemiological studies use exposure determinants specifically tailored to assess pesticide or plant protection product (PPP) exposures when assessing presumed association between occupational exposure and health outcomes among agricultural workers. This lack of exposure specificity could lead to results that fail to detect an association. It could be related to the lack of consensus on exposure assessment methods and the choice of exposure determinants. We conducted a meta-analysis following the PRISMA checklist to identify PPP exposure determinants used in occupational studies and identified exposure determinants that best characterized agricultural exposures to PPPs. Out of 1436 studies identified, 71 were included. The exposure determinants identified were active ingredients, chemical classes, types of PPP, crops, tasks, frequencies, duration, lifetime exposure days, and intensity-weighted exposure days. Only six over 17 associations between exposure determinants and health outcomes were found with moderate quality of evidence. Overall, epidemiological studies had difficulty defining relevant determinants to characterize PPP exposures for agricultural workers. We recommend that a standardized list of determinants for PPP exposures in occupational exposure studies should include information on formulations, intensity, duration, and frequency of PPP exposure. Harmonized data collection on exposure and health outcomes are required as well as standard units for each exposure determinant. MDPI 2023-07-18 /pmc/articles/PMC10386710/ /pubmed/37505588 http://dx.doi.org/10.3390/toxics11070623 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Oltramare, Christelle
Mediouni, Zakia
Shoman, Yara
Hopf, Nancy B.
Graczyk, Halshka
Berthet, Aurélie
Determinants of Pesticide Exposure in Occupational Studies: A Meta-Analysis
title Determinants of Pesticide Exposure in Occupational Studies: A Meta-Analysis
title_full Determinants of Pesticide Exposure in Occupational Studies: A Meta-Analysis
title_fullStr Determinants of Pesticide Exposure in Occupational Studies: A Meta-Analysis
title_full_unstemmed Determinants of Pesticide Exposure in Occupational Studies: A Meta-Analysis
title_short Determinants of Pesticide Exposure in Occupational Studies: A Meta-Analysis
title_sort determinants of pesticide exposure in occupational studies: a meta-analysis
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10386710/
https://www.ncbi.nlm.nih.gov/pubmed/37505588
http://dx.doi.org/10.3390/toxics11070623
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