K(ATP) channels are necessary for glucose-dependent increases in amyloid-β and Alzheimer’s disease–related pathology

Elevated blood glucose levels, or hyperglycemia, can increase brain excitability and amyloid-β (Aβ) release, offering a mechanistic link between type 2 diabetes and Alzheimer’s disease (AD). Since the cellular mechanisms governing this relationship are poorly understood, we explored whether ATP-sens...

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Detalles Bibliográficos
Autores principales: Grizzanti, John, Moritz, William R., Pait, Morgan C., Stanley, Molly, Kaye, Sarah D., Carroll, Caitlin M., Constantino, Nicholas J., Deitelzweig, Lily J., Snipes, James A., Kellar, Derek, Caesar, Emily E., Pettit-Mee, Ryan J., Day, Stephen M., Sens, Jonathon P., Nicol, Noelle I., Dhillon, Jasmeen, Remedi, Maria S., Kiraly, Drew D., Karch, Celeste M., Nichols, Colin G., Holtzman, David M., Macauley, Shannon L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10386887/
https://www.ncbi.nlm.nih.gov/pubmed/37129980
http://dx.doi.org/10.1172/jci.insight.162454

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