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Epigenetic activation of secretory phenotypes in senescence by the FOXQ1-SIRT4-GDH signaling

Although metabolic reprogramming is characterized as a hallmark of aging, implications of the crucial glutamate dehydrogenase (GDH) in human senescence remain poorly understood. Here, we report that GDH activity is significantly increased in aged mice and senescent human diploid fibroblasts. This en...

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Detalles Bibliográficos
Autores principales:	Sun, Xinpei, Li, Qian, Tang, Yunyi, Hu, Wanjin, Chen, Gengyao, An, Hongguang, Huang, Daoyuan, Tong, Tanjun, Zhang, Yu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10387070/ https://www.ncbi.nlm.nih.gov/pubmed/37516739 http://dx.doi.org/10.1038/s41419-023-06002-9

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