CXCL9 inhibition does not ameliorate disease in murine models of both primary and secondary hemophagocytic lymphohistiocytosis

Hemophagocytic Lymphohistiocytosis (HLH) is a group of disorders culminating in systemic inflammation and multi-organ failure with high incidence of hepatic dysfunction. Overproduction of IFN-γ is the main immunopathological driver in this disorder. Monokine induced by IFN-γ (CXCL9) serves as a biom...

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Detalles Bibliográficos
Autores principales: Diamond, Tamir, Lau, Michelle, Morrissette, Jeremy, Chu, Niansheng, Behrens, Edward M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10387083/
https://www.ncbi.nlm.nih.gov/pubmed/37516815
http://dx.doi.org/10.1038/s41598-023-39601-9

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