Cryo-EM structure of a RAS/RAF recruitment complex

RAF-family kinases are activated by recruitment to the plasma membrane by GTP-bound RAS, whereupon they initiate signaling through the MAP kinase cascade. Prior structural studies of KRAS with RAF have focused on the isolated RAS-binding and cysteine-rich domains of RAF (RBD and CRD, respectively),...

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Detalles Bibliográficos
Autores principales: Park, Eunyoung, Rawson, Shaun, Schmoker, Anna, Kim, Byeong-Won, Oh, Sehee, Song, Kangkang, Jeon, Hyesung, Eck, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10387098/
https://www.ncbi.nlm.nih.gov/pubmed/37516774
http://dx.doi.org/10.1038/s41467-023-40299-6

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