A trypanosome-derived immunotherapeutics platform elicits potent high-affinity antibodies, negating the effects of the synthetic opioid fentanyl

Poorly immunogenic small molecules pose challenges for the production of clinically efficacious vaccines and antibodies. To address this, we generate an immunization platform derived from the immunogenic surface coat of the African trypanosome. Through sortase-based conjugation of the target molecul...

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Detalles Bibliográficos
Autores principales: Triller, Gianna, Vlachou, Evi P., Hashemi, Hamidreza, van Straaten, Monique, Zeelen, Johan P., Kelemen, Yosip, Baehr, Carly, Marker, Cheryl L., Ruf, Sandra, Svirina, Anna, Chandra, Monica, Urban, Katharina, Gkeka, Anastasia, Kruse, Sebastian, Baumann, Andreas, Miller, Aubry K., Bartel, Marc, Pravetoni, Marco, Stebbins, C. Erec, Papavasiliou, F. Nina, Verdi, Joseph P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10387133/
https://www.ncbi.nlm.nih.gov/pubmed/36719797
http://dx.doi.org/10.1016/j.celrep.2023.112049

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