Thyroid Hormones and Cardiometabolic Risk Factors in Saudi Women with Polycystic Ovary Syndrome: A Cross-Sectional Study

OBJECTIVE: The PCOS-thyroid nexus has recently drawn the focus of various investigations due to the prevalence of thyroid problems in PCOS. Additionally, risk factors for cardiovascular disease (CVD) are more prevalent in PCOS women. Therefore, we aim to assess the levels of thyroid hormones in Saudi females with polycystic ovary syndrome (PCOS) and to examine the correlation between cardiometabolic risk factors (CMRFs) and thyroid hormones in PCOS patients. METHODS: A cross-sectional research with 200 PCOS-diagnosed female patients was conducted from April 2018 to April 2020. In addition to other anthropometric and serum biochemical markers, glycemic status, thyroid function test, lipid profiles, homocysteine, and C-reactive protein levels were detected in patients. RESULTS: In PCOS, hypothyroidism is more common than hyperthyroidism (55 vs 27.5%, p = 0.05). While women with raised TSH (hypothyroidism) had a higher BMI, WC, FBG, and poorer HDL-C (p< 0.05). Significant differences were found in LDL-C, TG, Homocysteine, and CRP levels (all p<0.001 and< 0.05). PCOS women with hypothyroidism at increased risk of CVD, as indicated by AIP (Atherogenic Index of plasma) (0.57±0.42) was found. The elevated TSH levels were favorably linked with TG, Homocysteine, CRP, BMI, AIP, and WC (all p< 0.001, 0.05) but negatively connected with HDL-C and FT4. CONCLUSION: A strong relationship between PCOS and thyroid dysfunction was detected since PCOS hypothyroid groups had higher TSH levels and CMRFs. This group’s CVD risk was elevated due to CRP, homocysteine, triglycerides, and obesity.