Cargando…
A Comparative Study of Intrathecal Fentanyl and Nalbuphine as an Adjuvant to Hyperbaric Bupivacaine for Spinal Anesthesia in Lower Limb Orthopedic Surgeries: A Prospective, Double-Blind, Randomized Controlled Study
Background: Spinal anaesthesia is the most commonly used technique for lower limb orthopaedic surgeries as it is economical and easy to administer. Opioids as adjuvants to local anaesthetics during spinal anaesthesia have played a vital role in reducing post-operative pain qualitatively and effectiv...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10387452/ https://www.ncbi.nlm.nih.gov/pubmed/37529511 http://dx.doi.org/10.7759/cureus.41230 |
_version_ | 1785081887456231424 |
---|---|
author | Satapathy, Subhaprada Nayak, Laba K Behera, Sanjaya K Satapathy, Ganesh C Swain, Rasulata Das, Saswati |
author_facet | Satapathy, Subhaprada Nayak, Laba K Behera, Sanjaya K Satapathy, Ganesh C Swain, Rasulata Das, Saswati |
author_sort | Satapathy, Subhaprada |
collection | PubMed |
description | Background: Spinal anaesthesia is the most commonly used technique for lower limb orthopaedic surgeries as it is economical and easy to administer. Opioids as adjuvants to local anaesthetics during spinal anaesthesia have played a vital role in reducing post-operative pain qualitatively and effectively. Methods: This prospective randomised study was conducted on 100 patients divided into two groups scheduled for lower limb orthopaedic surgeries. Group bupivacaine fentanyl (BF) received 25 mcg of fentanyl with 15 mg of bupivacaine and Group bupivacaine nalbuphine (BN) received 1 mg of nalbuphine and 15 mg of 0.5% bupivacaine. The aim of the study was to compare the analgesic efficacy of intrathecal fentanyl and nalbuphine as an adjuvant to hyperbaric bupivacaine for spinal anaesthesia. Duration of effective analgesia, haemodynamic parameters, onset and duration of sensory and motor block, adverse effects, and visual analogue scale (VAS) score were assessed. Results: Duration of effective analgesia was 388±24.88 minutes in the BN group and was higher (p-value <0.001) in comparison to the BF group, which was 304.70±15.76 minutes. Conclusion: Nalbuphine was more effective than fentanyl in providing post-operative analgesia when used as an adjuvant to hyperbaric bupivacaine. |
format | Online Article Text |
id | pubmed-10387452 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-103874522023-08-01 A Comparative Study of Intrathecal Fentanyl and Nalbuphine as an Adjuvant to Hyperbaric Bupivacaine for Spinal Anesthesia in Lower Limb Orthopedic Surgeries: A Prospective, Double-Blind, Randomized Controlled Study Satapathy, Subhaprada Nayak, Laba K Behera, Sanjaya K Satapathy, Ganesh C Swain, Rasulata Das, Saswati Cureus Anesthesiology Background: Spinal anaesthesia is the most commonly used technique for lower limb orthopaedic surgeries as it is economical and easy to administer. Opioids as adjuvants to local anaesthetics during spinal anaesthesia have played a vital role in reducing post-operative pain qualitatively and effectively. Methods: This prospective randomised study was conducted on 100 patients divided into two groups scheduled for lower limb orthopaedic surgeries. Group bupivacaine fentanyl (BF) received 25 mcg of fentanyl with 15 mg of bupivacaine and Group bupivacaine nalbuphine (BN) received 1 mg of nalbuphine and 15 mg of 0.5% bupivacaine. The aim of the study was to compare the analgesic efficacy of intrathecal fentanyl and nalbuphine as an adjuvant to hyperbaric bupivacaine for spinal anaesthesia. Duration of effective analgesia, haemodynamic parameters, onset and duration of sensory and motor block, adverse effects, and visual analogue scale (VAS) score were assessed. Results: Duration of effective analgesia was 388±24.88 minutes in the BN group and was higher (p-value <0.001) in comparison to the BF group, which was 304.70±15.76 minutes. Conclusion: Nalbuphine was more effective than fentanyl in providing post-operative analgesia when used as an adjuvant to hyperbaric bupivacaine. Cureus 2023-06-30 /pmc/articles/PMC10387452/ /pubmed/37529511 http://dx.doi.org/10.7759/cureus.41230 Text en Copyright © 2023, Satapathy et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Anesthesiology Satapathy, Subhaprada Nayak, Laba K Behera, Sanjaya K Satapathy, Ganesh C Swain, Rasulata Das, Saswati A Comparative Study of Intrathecal Fentanyl and Nalbuphine as an Adjuvant to Hyperbaric Bupivacaine for Spinal Anesthesia in Lower Limb Orthopedic Surgeries: A Prospective, Double-Blind, Randomized Controlled Study |
title | A Comparative Study of Intrathecal Fentanyl and Nalbuphine as an Adjuvant to Hyperbaric Bupivacaine for Spinal Anesthesia in Lower Limb Orthopedic Surgeries: A Prospective, Double-Blind, Randomized Controlled Study |
title_full | A Comparative Study of Intrathecal Fentanyl and Nalbuphine as an Adjuvant to Hyperbaric Bupivacaine for Spinal Anesthesia in Lower Limb Orthopedic Surgeries: A Prospective, Double-Blind, Randomized Controlled Study |
title_fullStr | A Comparative Study of Intrathecal Fentanyl and Nalbuphine as an Adjuvant to Hyperbaric Bupivacaine for Spinal Anesthesia in Lower Limb Orthopedic Surgeries: A Prospective, Double-Blind, Randomized Controlled Study |
title_full_unstemmed | A Comparative Study of Intrathecal Fentanyl and Nalbuphine as an Adjuvant to Hyperbaric Bupivacaine for Spinal Anesthesia in Lower Limb Orthopedic Surgeries: A Prospective, Double-Blind, Randomized Controlled Study |
title_short | A Comparative Study of Intrathecal Fentanyl and Nalbuphine as an Adjuvant to Hyperbaric Bupivacaine for Spinal Anesthesia in Lower Limb Orthopedic Surgeries: A Prospective, Double-Blind, Randomized Controlled Study |
title_sort | comparative study of intrathecal fentanyl and nalbuphine as an adjuvant to hyperbaric bupivacaine for spinal anesthesia in lower limb orthopedic surgeries: a prospective, double-blind, randomized controlled study |
topic | Anesthesiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10387452/ https://www.ncbi.nlm.nih.gov/pubmed/37529511 http://dx.doi.org/10.7759/cureus.41230 |
work_keys_str_mv | AT satapathysubhaprada acomparativestudyofintrathecalfentanylandnalbuphineasanadjuvanttohyperbaricbupivacaineforspinalanesthesiainlowerlimborthopedicsurgeriesaprospectivedoubleblindrandomizedcontrolledstudy AT nayaklabak acomparativestudyofintrathecalfentanylandnalbuphineasanadjuvanttohyperbaricbupivacaineforspinalanesthesiainlowerlimborthopedicsurgeriesaprospectivedoubleblindrandomizedcontrolledstudy AT beherasanjayak acomparativestudyofintrathecalfentanylandnalbuphineasanadjuvanttohyperbaricbupivacaineforspinalanesthesiainlowerlimborthopedicsurgeriesaprospectivedoubleblindrandomizedcontrolledstudy AT satapathyganeshc acomparativestudyofintrathecalfentanylandnalbuphineasanadjuvanttohyperbaricbupivacaineforspinalanesthesiainlowerlimborthopedicsurgeriesaprospectivedoubleblindrandomizedcontrolledstudy AT swainrasulata acomparativestudyofintrathecalfentanylandnalbuphineasanadjuvanttohyperbaricbupivacaineforspinalanesthesiainlowerlimborthopedicsurgeriesaprospectivedoubleblindrandomizedcontrolledstudy AT dassaswati acomparativestudyofintrathecalfentanylandnalbuphineasanadjuvanttohyperbaricbupivacaineforspinalanesthesiainlowerlimborthopedicsurgeriesaprospectivedoubleblindrandomizedcontrolledstudy AT satapathysubhaprada comparativestudyofintrathecalfentanylandnalbuphineasanadjuvanttohyperbaricbupivacaineforspinalanesthesiainlowerlimborthopedicsurgeriesaprospectivedoubleblindrandomizedcontrolledstudy AT nayaklabak comparativestudyofintrathecalfentanylandnalbuphineasanadjuvanttohyperbaricbupivacaineforspinalanesthesiainlowerlimborthopedicsurgeriesaprospectivedoubleblindrandomizedcontrolledstudy AT beherasanjayak comparativestudyofintrathecalfentanylandnalbuphineasanadjuvanttohyperbaricbupivacaineforspinalanesthesiainlowerlimborthopedicsurgeriesaprospectivedoubleblindrandomizedcontrolledstudy AT satapathyganeshc comparativestudyofintrathecalfentanylandnalbuphineasanadjuvanttohyperbaricbupivacaineforspinalanesthesiainlowerlimborthopedicsurgeriesaprospectivedoubleblindrandomizedcontrolledstudy AT swainrasulata comparativestudyofintrathecalfentanylandnalbuphineasanadjuvanttohyperbaricbupivacaineforspinalanesthesiainlowerlimborthopedicsurgeriesaprospectivedoubleblindrandomizedcontrolledstudy AT dassaswati comparativestudyofintrathecalfentanylandnalbuphineasanadjuvanttohyperbaricbupivacaineforspinalanesthesiainlowerlimborthopedicsurgeriesaprospectivedoubleblindrandomizedcontrolledstudy |