Mannosylated glycans impair normal T-cell development by reprogramming commitment and repertoire diversity

T-cell development ensures the formation of diverse repertoires of T-cell receptors (TCRs) that recognize a variety of antigens. Glycosylation is a major posttranslational modification present in virtually all cells, including T-lymphocytes, that regulates activity/functions. Although these structur...

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Detalles Bibliográficos
Autores principales: Vicente, Manuel M., Alves, Inês, Fernandes, Ângela, Dias, Ana M., Santos-Pereira, Beatriz, Pérez-Anton, Elena, Santos, Sofia, Yang, Tao, Correia, Alexandra, Münster-Kühnel, Anja, Almeida, Afonso R. M., Ravens, Sarina, Rabinovich, Gabriel A., Vilanova, Manuel, Sousa, Ana E., Pinho, Salomé S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10387478/
https://www.ncbi.nlm.nih.gov/pubmed/37344746
http://dx.doi.org/10.1038/s41423-023-01052-7

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