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PASCAR: a multiscale framework to explore the design space of constitutive and inducible CAR T cells

CAR T cells are engineered to bind and destroy tumor cells by targeting overexpressed surface antigens. However, healthy cells expressing lower abundances of these antigens can also be lysed by CAR T cells. Various CAR T cell designs increase tumor cell elimination, whereas reducing damage to health...

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Detalles Bibliográficos
Autores principales: Rajakaruna, Harshana, Desai, Milie, Das, Jayajit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10387492/
https://www.ncbi.nlm.nih.gov/pubmed/37507138
http://dx.doi.org/10.26508/lsa.202302171

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