SALL4 as an indicator for the diagnosis of hepatoid carcinoma of the ovary: A case report and literature review

KEY CLINICAL MESSAGE: Primary HCO is a rare, aggressive ovarian malignant tumor, morphologically resembling HCC. SALL4 can be adopted to differentiate HCO from HCC. The serum AFP and CA125 rather than HE4 can be employed as possible biomarkers to track treatment and monitor recurrence. ABSTRACT: We...

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Detalles Bibliográficos
Autores principales: Li, Jiana, Wu, Xiaohua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10387514/
https://www.ncbi.nlm.nih.gov/pubmed/37529124
http://dx.doi.org/10.1002/ccr3.7706
Descripción
Sumario:KEY CLINICAL MESSAGE: Primary HCO is a rare, aggressive ovarian malignant tumor, morphologically resembling HCC. SALL4 can be adopted to differentiate HCO from HCC. The serum AFP and CA125 rather than HE4 can be employed as possible biomarkers to track treatment and monitor recurrence. ABSTRACT: We report a case of a postmenopausal woman presenting with lower abdominal pain and vaginal bleeding. She went through a maximal debulking surgery, and the pathological biopsy revealed hepatoid carcinoma of the ovary (HCO). Immunohistochemical assay demonstrates SALL4 as an indicator to differentiate HCO from hepatocellular carcinoma (HCC).

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