Ebola virus shed glycoprotein is toxic to human T, B, and natural killer lymphocytes

Lymphocyte depletion is a distinctive feature of Ebola virus (EBOV) disease. The ectodomain of EBOV glycoprotein (GP) is cleaved off the surface of infected cells into circulation as shed GP. To test the hypothesis that shed GP induces lymphocyte death, we cultured primary human B, NK, or T cells wi...

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Detalles Bibliográficos
Autores principales: Perez-Valencia, Luis J., Vannella, Kevin M., Ramos-Benitez, Marcos J., Sun, Junfeng, Abu-Asab, Mones, Dorward, David W., Awad, Keytam S., Platt, Andrew, Jacobson, Eliana, Kindrachuk, Jason, Chertow, Daniel S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10387567/
https://www.ncbi.nlm.nih.gov/pubmed/37529105
http://dx.doi.org/10.1016/j.isci.2023.107323

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