Cargando…

Impaired regulatory function of granzyme B-producing B cells against T cell inflammatory responses in lupus mice

OBJECTIVE: Recently, a new subtype of granzyme B (GrB)-producing Breg cells has been identified, which was proven to be involved in autoimmune disease. Our recent report demonstrated that GrB-producing Breg cells were correlated with clinical and immunological features of SLE. However, the effect of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xue, Jimeng, Xu, Liling, Zhong, Hua, Bai, Mingxin, Li, Xin, Yao, Ranran, Wang, Ziye, Zhao, Zhen, Li, Hongchao, Zhu, Huaqun, Hu, Fanlei, Su, Yin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2023
Materias:	Immunology and Inflammation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10387741/ https://www.ncbi.nlm.nih.gov/pubmed/37500293 http://dx.doi.org/10.1136/lupus-2023-000974

Ejemplares similares

Impairment of Granzyme B-Producing Regulatory B Cells Correlates with Exacerbated Rheumatoid Arthritis
por: Xu, Liling, et al.
Publicado: (2017)

Studying the biology of cytotoxic T lymphocytes in vivo with a fluorescent granzyme B-mTFP knock-in mouse
por: Chitirala, Praneeth, et al.
Publicado: (2020)

CD16(+) Monocyte Subset Was Enriched and Functionally Exacerbated in Driving T-Cell Activation and B-Cell Response in Systemic Lupus Erythematosus
por: Zhu, Huaqun, et al.
Publicado: (2016)

CD14(+)CD16(−) monocytes are the main precursors of osteoclasts in rheumatoid arthritis via expressing Tyro3TK
por: Xue, Jimeng, et al.
Publicado: (2020)

IL-33 induces granzyme C expression in murine mast cells via an MSK1/2-CREB-dependent pathway
por: Phair, Iain R., et al.
Publicado: (2022)

Effects of targeting the transcription factors Ikaros and Aiolos on B cell activation and differentiation in systemic lupus erythematosus
por: Rivellese, Felice, et al.
Publicado: (2021)

Widespread discrepancy in Nnt genotypes and genetic backgrounds complicates granzyme A and other knockout mouse studies
por: Rawle, Daniel J, et al.
Publicado: (2022)

Metformin abrogates pathological TNF-α-producing B cells through mTOR-dependent metabolic reprogramming in polycystic ovary syndrome
por: Xiao, Na, et al.
Publicado: (2022)

Conformational change within the extracellular domain of B cell receptor in B cell activation upon antigen binding
por: Shen, Zhixun, et al.
Publicado: (2019)

Plasmodium-specific atypical memory B cells are short-lived activated B cells
por: Pérez-Mazliah, Damián, et al.
Publicado: (2018)

Impaired CD27(+)IgD(+) B Cells With Altered Gene Signature in Rheumatoid Arthritis
por: Hu, Fanlei, et al.
Publicado: (2018)

Role of autoantibodies and blood–brain barrier leakage in cognitive impairment in systemic lupus erythematosus
por: Hanly, John G, et al.
Publicado: (2022)

The role of B cells in immune cell activation in polycystic ovary syndrome
por: Ascani, Angelo, et al.
Publicado: (2023)

IgM and IgD B cell receptors differentially respond to endogenous antigens and control B cell fate
por: Noviski, Mark, et al.
Publicado: (2018)

Tuning of in vivo cognate B-T cell interactions by Intersectin 2 is required for effective anti-viral B cell immunity
por: Burbage, Marianne, et al.
Publicado: (2018)

Regulatory T cells in lung disease and transplantation
por: Lao, Peizhen, et al.
Publicado: (2023)

Reprogramming the antigen specificity of B cells using genome-editing technologies
por: Voss, James E, et al.
Publicado: (2019)

Lupus serum induces inflammatory interaction with neutrophils in human glomerular endothelial cells
por: Russell, Dayvia A, et al.
Publicado: (2020)

Granzymes are necessary for suppressive function of regulatory T cells
por: Co, Dominic O, et al.
Publicado: (2012)

Reduced response to Epstein–Barr virus antigens by T-cells in systemic lupus erythematosus patients
por: Draborg, Anette Holck, et al.
Publicado: (2014)

Intraocular dendritic cells characterize HLA-B27-associated acute anterior uveitis
por: Kasper, Maren, et al.
Publicado: (2021)

B cell receptor and Toll-like receptor signaling coordinate to control distinct B-1 responses to both self and the microbiota
por: Kreuk, Lieselotte SM, et al.
Publicado: (2019)

mTORC1 Inhibition Protects Human Regulatory T Cells From Granzyme-B-Induced Apoptosis
por: Eskandari, Siawosh K., et al.
Publicado: (2022)

B cells suppress medullary granulopoiesis by an extracellular glycosylation-dependent mechanism
por: Irons, Eric E, et al.
Publicado: (2019)

High-dimensional analysis of T-cell profiling variations following belimumab treatment in systemic lupus erythematosus
por: Maeda, Shinji, et al.
Publicado: (2023)

Abnormally high expression of D1-like dopamine receptors on lupus CD4(+) T cells promotes Tfh cell differentiation
por: Wu, Fengxi, et al.
Publicado: (2023)

The quantity of CD40 signaling determines the differentiation of B cells into functionally distinct memory cell subsets
por: Koike, Takuya, et al.
Publicado: (2019)

CD4(+) T-cell cooperation promoted pathogenic function of activated naïve B cells of patients with SLE
por: Wangriatisak, Kittikorn, et al.
Publicado: (2022)

NAD(+) attenuates experimental autoimmune encephalomyelitis through induction of CD11b(+) gr-1(+) myeloid-derived suppressor cells
por: Wang, Jin-Li, et al.
Publicado: (2020)

Apoptotic pathways are selectively activated by granzyme A and/or granzyme B in CTL-mediated target cell lysis
por: Pardo, Julián, et al.
Publicado: (2004)

Latent gammaherpesvirus exacerbates arthritis through modification of age-associated B cells
por: Mouat, Isobel C, et al.
Publicado: (2021)

Phorbol-12-myristate-13-acetate is a potent enhancer of B cells with a granzyme B(+) regulatory phenotype
por: Veh, Johanna, et al.
Publicado: (2023)

Peripheral natural killer cells in chronic hepatitis B patients display multiple molecular features of T cell exhaustion
por: Marotel, Marie, et al.
Publicado: (2021)

Granzyme B mediates impaired healing of pressure injuries in aged skin
por: Turner, Christopher T., et al.
Publicado: (2021)

Gut Helicobacter presentation by multiple dendritic cell subsets enables context-specific regulatory T cell generation
por: Russler-Germain, Emilie V, et al.
Publicado: (2021)

Variations in HLA-B cell surface expression, half-life and extracellular antigen receptivity
por: Yarzabek, Brogan, et al.
Publicado: (2018)

Identification of scavenger receptor B1 as the airway microfold cell receptor for Mycobacterium tuberculosis
por: Khan, Haaris S, et al.
Publicado: (2020)

Different B cell subpopulations show distinct patterns in their IgH repertoire metrics
por: Ghraichy, Marie, et al.
Publicado: (2021)

TCF7 is highly expressed in immune cells on the atherosclerotic plaques, and regulating inflammatory signaling via NFκB/AKT/STAT1 signaling
por: Ma, Zhongnan, et al.
Publicado: (2022)

Quantitative modeling of the effect of antigen dosage on B-cell affinity distributions in maturating germinal centers
por: Molari, Marco, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_qnqtnef2umkn0l2gon9ma762lt