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Evaluation of toxic effects of dapagliflozin on reproductive system in diabetic rats

BACKGROUND/AIM: Dapagliflozin (DAPA), sodium-glucose cotransporter 2 (SGLT2) inhibitor, is an insulin-independent antidiabetic drug used to control hyperglycaemia by promoting glucose excretion from the kidney. Its adverse effects include orthostatic hypotension, dehydration and urinary tract and ge...

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Autores principales: ULUS KARACA, Bahar, BORAN, Tuğçe, KARAGÖZ KÖROĞLU, Ayça, ERCAN, Feriha, ÖZHAN, Gül
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Scientific and Technological Research Council of Turkey (TUBITAK) 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10387970/
https://www.ncbi.nlm.nih.gov/pubmed/36326417
http://dx.doi.org/10.55730/1300-0144.5443
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author ULUS KARACA, Bahar
BORAN, Tuğçe
KARAGÖZ KÖROĞLU, Ayça
ERCAN, Feriha
ÖZHAN, Gül
author_facet ULUS KARACA, Bahar
BORAN, Tuğçe
KARAGÖZ KÖROĞLU, Ayça
ERCAN, Feriha
ÖZHAN, Gül
author_sort ULUS KARACA, Bahar
collection PubMed
description BACKGROUND/AIM: Dapagliflozin (DAPA), sodium-glucose cotransporter 2 (SGLT2) inhibitor, is an insulin-independent antidiabetic drug used to control hyperglycaemia by promoting glucose excretion from the kidney. Its adverse effects include orthostatic hypotension, dehydration and urinary tract and genital infections caused by glycosuria. DAPA is subjected to constant additional monitoring, as drug-related adverse reactions are frequently updated in line with the results of case studies, clinical trials and in vivo studies. Some antidiabetic drugs have shown potential harmful effects on the male reproductive system; however, the effects of DAPA have not been sufficiently studied in this capacity. Aiming to fill this gap in the literature, the present work investigates the toxic effects of DAPA on the male reproductive system. MATERIALS AND METHODS: Diabetes was induced using streptozotocin (STZ) in adult male Sprague-Dawley (SD) rats. DAPA (10 mg/kg) was administered by gavage to the diabetic rats over 28 days, after which the animals were sacrificed. The biochemical, morphological and histological examinations were performed on testicle, sperm and plasma samples. RESULTS: As a result of this study, we observed reproductive system damage in the form of induction of apoptosis in the seminiferous tubules, changes in testis and sperm parameters and oxidative damage, alongside the development of diabetes in test animals. With the exception of sperm morphological damage, the changes observed in diabetic animals treated with DAPA were similar to those of the control group. Improvements were observed in histological, hormonal and proliferative parameters in the DAPA group compared to the DC group. CONCLUSION: Even if DAPA is found to have antioxidant effects, it may raise abnormal sperm counts through a mechanism completely independent of these effects and thus may not have a significant toxic effect on the male reproductive system.
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spelling pubmed-103879702023-08-01 Evaluation of toxic effects of dapagliflozin on reproductive system in diabetic rats ULUS KARACA, Bahar BORAN, Tuğçe KARAGÖZ KÖROĞLU, Ayça ERCAN, Feriha ÖZHAN, Gül Turk J Med Sci Research Article BACKGROUND/AIM: Dapagliflozin (DAPA), sodium-glucose cotransporter 2 (SGLT2) inhibitor, is an insulin-independent antidiabetic drug used to control hyperglycaemia by promoting glucose excretion from the kidney. Its adverse effects include orthostatic hypotension, dehydration and urinary tract and genital infections caused by glycosuria. DAPA is subjected to constant additional monitoring, as drug-related adverse reactions are frequently updated in line with the results of case studies, clinical trials and in vivo studies. Some antidiabetic drugs have shown potential harmful effects on the male reproductive system; however, the effects of DAPA have not been sufficiently studied in this capacity. Aiming to fill this gap in the literature, the present work investigates the toxic effects of DAPA on the male reproductive system. MATERIALS AND METHODS: Diabetes was induced using streptozotocin (STZ) in adult male Sprague-Dawley (SD) rats. DAPA (10 mg/kg) was administered by gavage to the diabetic rats over 28 days, after which the animals were sacrificed. The biochemical, morphological and histological examinations were performed on testicle, sperm and plasma samples. RESULTS: As a result of this study, we observed reproductive system damage in the form of induction of apoptosis in the seminiferous tubules, changes in testis and sperm parameters and oxidative damage, alongside the development of diabetes in test animals. With the exception of sperm morphological damage, the changes observed in diabetic animals treated with DAPA were similar to those of the control group. Improvements were observed in histological, hormonal and proliferative parameters in the DAPA group compared to the DC group. CONCLUSION: Even if DAPA is found to have antioxidant effects, it may raise abnormal sperm counts through a mechanism completely independent of these effects and thus may not have a significant toxic effect on the male reproductive system. Scientific and Technological Research Council of Turkey (TUBITAK) 2022-03-12 /pmc/articles/PMC10387970/ /pubmed/36326417 http://dx.doi.org/10.55730/1300-0144.5443 Text en © TÜBİTAK https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License.
spellingShingle Research Article
ULUS KARACA, Bahar
BORAN, Tuğçe
KARAGÖZ KÖROĞLU, Ayça
ERCAN, Feriha
ÖZHAN, Gül
Evaluation of toxic effects of dapagliflozin on reproductive system in diabetic rats
title Evaluation of toxic effects of dapagliflozin on reproductive system in diabetic rats
title_full Evaluation of toxic effects of dapagliflozin on reproductive system in diabetic rats
title_fullStr Evaluation of toxic effects of dapagliflozin on reproductive system in diabetic rats
title_full_unstemmed Evaluation of toxic effects of dapagliflozin on reproductive system in diabetic rats
title_short Evaluation of toxic effects of dapagliflozin on reproductive system in diabetic rats
title_sort evaluation of toxic effects of dapagliflozin on reproductive system in diabetic rats
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10387970/
https://www.ncbi.nlm.nih.gov/pubmed/36326417
http://dx.doi.org/10.55730/1300-0144.5443
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