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Evaluation of the relationship between vitamin D level and adropin, IL-1β, IL-6, and oxidative status in women
BACKGROUND/AIM: Vitamin D, adropin, proinflammatory cytokines, and oxidative stress closely related with metabolic homeostasis and endothelial dysfunction. The aim of the present study is to investigate how vitamin D levels affect serum adropin, IL-1ß, IL-6, and oxidative stress. MATERIALS AND METHO...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Scientific and Technological Research Council of Turkey (TUBITAK)
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10388050/ https://www.ncbi.nlm.nih.gov/pubmed/36326375 http://dx.doi.org/10.55730/1300-0144.5424 |
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author | ZORLU, Mehmet ŞEKERCİ, Abdüsselam TUNÇ, Muhammed GÜLER, Eray Metin GÜLEN, Bedia KARATOPRAK, Cumali KISKAÇ, Muharrem ÇAKIRCA, Mustafa |
author_facet | ZORLU, Mehmet ŞEKERCİ, Abdüsselam TUNÇ, Muhammed GÜLER, Eray Metin GÜLEN, Bedia KARATOPRAK, Cumali KISKAÇ, Muharrem ÇAKIRCA, Mustafa |
author_sort | ZORLU, Mehmet |
collection | PubMed |
description | BACKGROUND/AIM: Vitamin D, adropin, proinflammatory cytokines, and oxidative stress closely related with metabolic homeostasis and endothelial dysfunction. The aim of the present study is to investigate how vitamin D levels affect serum adropin, IL-1ß, IL-6, and oxidative stress. MATERIALS AND METHODS: A total of 77 female subjects were divided into 3 groups according to vitamin D levels. Biochemical parameters, adropin, IL-1ß, IL-6, oxidative stress markers were studied in these groups, and the results were compared statistically. RESULTS: Serum adropin, IL-1ß, IL-6, total oxidant status (TOS) and total antioxidant status (TAS) and oxidative stress index (OSI) levels differed significantly between the vitamin D groups (p < 0.05). A significant positive correlation was detected between vitamin D, and adropin and TAS (r = 0.807; p < 0.001, r = 0.814; p < 0.001, respectively). A significant negative correlation was detected between vitamin D, and IL-1ß, IL-6, TOS, OSI (r = −0.725; p < 0.001, r = −0.720; p < 0.001, r = −0.238; p = 0.037, r = −0.705; p < 0.001, respectively). CONCLUSIONS: Vitamin D could show its effects through vitamin D receptors on tissues or on the ENHO gene in adropin secreting tissues via direct or indirect mechanisms. Proinflammatory cytokines, oxidative stress, and adropin targeted studies could contribute to the prevention and treatment of diseases associated with vitamin D deficiency in future. |
format | Online Article Text |
id | pubmed-10388050 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Scientific and Technological Research Council of Turkey (TUBITAK) |
record_format | MEDLINE/PubMed |
spelling | pubmed-103880502023-08-01 Evaluation of the relationship between vitamin D level and adropin, IL-1β, IL-6, and oxidative status in women ZORLU, Mehmet ŞEKERCİ, Abdüsselam TUNÇ, Muhammed GÜLER, Eray Metin GÜLEN, Bedia KARATOPRAK, Cumali KISKAÇ, Muharrem ÇAKIRCA, Mustafa Turk J Med Sci Research Article BACKGROUND/AIM: Vitamin D, adropin, proinflammatory cytokines, and oxidative stress closely related with metabolic homeostasis and endothelial dysfunction. The aim of the present study is to investigate how vitamin D levels affect serum adropin, IL-1ß, IL-6, and oxidative stress. MATERIALS AND METHODS: A total of 77 female subjects were divided into 3 groups according to vitamin D levels. Biochemical parameters, adropin, IL-1ß, IL-6, oxidative stress markers were studied in these groups, and the results were compared statistically. RESULTS: Serum adropin, IL-1ß, IL-6, total oxidant status (TOS) and total antioxidant status (TAS) and oxidative stress index (OSI) levels differed significantly between the vitamin D groups (p < 0.05). A significant positive correlation was detected between vitamin D, and adropin and TAS (r = 0.807; p < 0.001, r = 0.814; p < 0.001, respectively). A significant negative correlation was detected between vitamin D, and IL-1ß, IL-6, TOS, OSI (r = −0.725; p < 0.001, r = −0.720; p < 0.001, r = −0.238; p = 0.037, r = −0.705; p < 0.001, respectively). CONCLUSIONS: Vitamin D could show its effects through vitamin D receptors on tissues or on the ENHO gene in adropin secreting tissues via direct or indirect mechanisms. Proinflammatory cytokines, oxidative stress, and adropin targeted studies could contribute to the prevention and treatment of diseases associated with vitamin D deficiency in future. Scientific and Technological Research Council of Turkey (TUBITAK) 2022-05-07 /pmc/articles/PMC10388050/ /pubmed/36326375 http://dx.doi.org/10.55730/1300-0144.5424 Text en © TÜBİTAK https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License. |
spellingShingle | Research Article ZORLU, Mehmet ŞEKERCİ, Abdüsselam TUNÇ, Muhammed GÜLER, Eray Metin GÜLEN, Bedia KARATOPRAK, Cumali KISKAÇ, Muharrem ÇAKIRCA, Mustafa Evaluation of the relationship between vitamin D level and adropin, IL-1β, IL-6, and oxidative status in women |
title | Evaluation of the relationship between vitamin D level and adropin, IL-1β, IL-6, and oxidative status in women |
title_full | Evaluation of the relationship between vitamin D level and adropin, IL-1β, IL-6, and oxidative status in women |
title_fullStr | Evaluation of the relationship between vitamin D level and adropin, IL-1β, IL-6, and oxidative status in women |
title_full_unstemmed | Evaluation of the relationship between vitamin D level and adropin, IL-1β, IL-6, and oxidative status in women |
title_short | Evaluation of the relationship between vitamin D level and adropin, IL-1β, IL-6, and oxidative status in women |
title_sort | evaluation of the relationship between vitamin d level and adropin, il-1β, il-6, and oxidative status in women |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10388050/ https://www.ncbi.nlm.nih.gov/pubmed/36326375 http://dx.doi.org/10.55730/1300-0144.5424 |
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