Single amino acid–based PROTACs trigger degradation of the oncogenic kinase BCR–ABL in chronic myeloid leukemia (CML)

Proteolysis-targeting chimera (PROTAC) that specifically targets harmful proteins for destruction by hijacking the ubiquitin–proteasome system is emerging as a potent anticancer strategy. How to efficiently modulate the target degradation remains a challenging issue. In this study, we employ a singl...

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Detalles Bibliográficos
Autores principales: Zhang, Jianchao, Ma, Caibing, Yu, Yongjun, Liu, Chaowei, Fang, Lijing, Rao, Hai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10388202/
https://www.ncbi.nlm.nih.gov/pubmed/37392851
http://dx.doi.org/10.1016/j.jbc.2023.104994

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10388202/
https://www.ncbi.nlm.nih.gov/pubmed/37392851
http://dx.doi.org/10.1016/j.jbc.2023.104994

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